{"id":"W3201878363","doi":"10.1055/s-0041-1725911","title":"MEK-Inhibition Treatment with Trametinib in a 7.7-Year-Old Girl with Noonan's Syndrome and Life-Threatening Lymphangiopathy","year":2021,"lang":"en","type":"article","venue":"The Thoracic and Cardiovascular Surgeon","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Noonan syndrome; Trametinib; Girl; MEK inhibitor; Pediatrics; Internal medicine; MAPK/ERK pathway; Genetics; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004620794,0.0002388497,0.000373023,0.00003728388,0.0001082824,0.00005192736,0.00005118738,0.00008849981,0.000005507019],"category_scores_gemma":[0.00002547353,0.0001523338,0.0001552491,0.0001872875,0.0001365318,0.00001095626,0.00007051486,0.00005780857,0.000001633804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000198337,"about_ca_system_score_gemma":0.0001020412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002409173,"about_ca_topic_score_gemma":0.00009057687,"domain_scores_codex":[0.9986444,0.0002323336,0.0001449962,0.0004958843,0.0002077246,0.0002746468],"domain_scores_gemma":[0.9992559,0.00002178,0.00004370838,0.0005203052,0.00005782121,0.0001004786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01010003,0.00124497,0.2284028,0.001013273,0.01521611,0.0129079,0.002159646,0.00270392,0.05269444,0.001902754,0.0001902173,0.6714639],"study_design_scores_gemma":[0.007951237,0.003092535,0.06631793,0.0007340206,0.00197441,0.008872649,0.00194909,0.00008576773,0.897773,0.0002300868,0.009492692,0.001526642],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8833591,0.1152965,0.0007986875,0.0001037862,0.00001821131,0.0002920848,0.00002439646,0.00001537899,0.00009184731],"genre_scores_gemma":[0.9950519,0.00405138,0.0004076338,0.00006537623,0.00004488916,0.0001104819,0.0001220857,0.00003335659,0.0001129269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8450785,"threshold_uncertainty_score":0.6211994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008465105882385193,"score_gpt":0.2119353427045255,"score_spread":0.2034702368221403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}