{"id":"W3201878363","doi":"10.1055/s-0041-1725911","title":"MEK-Inhibition Treatment with Trametinib in a 7.7-Year-Old Girl with Noonan's Syndrome and Life-Threatening Lymphangiopathy","year":2021,"lang":"en","type":"article","venue":"The Thoracic and Cardiovascular Surgeon","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Noonan syndrome; Trametinib; Girl; MEK inhibitor; Pediatrics; Internal medicine; MAPK/ERK pathway; Genetics; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001279564,0.0008387268,0.00076111,0.0005607824,0.00109839,0.0004838689,0.0005219365,0.002315942,0.001006469],"category_scores_gemma":[0.000748876,0.0003643956,0.0007191306,0.0002621993,0.0005261523,0.0006539704,0.0004324338,0.002384582,0.0003719224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00087659,"about_ca_system_score_gemma":0.0006959743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002437245,"about_ca_topic_score_gemma":0.004211257,"domain_scores_codex":[0.9998485,0.00001503591,0.00001608195,0.00003732161,0.0000259717,0.00005701323],"domain_scores_gemma":[0.9996183,0.00008183035,0.00004690037,0.000009952002,0.00002228965,0.0002206863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001534033,0.0000668979,0.006473641,0.00002354482,0.00001094677,0.9875244,0.0000832739,0.0001393823,0.002358641,0.0001832196,0.0005884123,0.002394206],"study_design_scores_gemma":[0.00005892185,0.0004786783,0.01882004,0.00004918731,0.00005988113,0.9749043,0.0002125548,0.001102896,0.001805971,0.0003396405,0.002148316,0.00001958261],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748113,0.003830113,0.001414083,0.01014817,0.0005042325,0.00007634484,0.000333647,0.0001286731,0.008753435],"genre_scores_gemma":[0.9931499,0.001710985,0.0006567704,0.001550433,0.0002057285,0.00001812455,0.0001415181,0.0000277075,0.002538668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002437245,"threshold_uncertainty_score":0.006360114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008465105882385193,"score_gpt":0.2119353427045255,"score_spread":0.2034702368221403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}