{"id":"W3201907175","doi":"10.1016/j.annonc.2021.08.2086","title":"LBA14 Neoadjuvant giredestrant (GDC-9545) + palbociclib (palbo) vs anastrozole (A) + palbo in post-menopausal women with oestrogen receptor-positive, HER2-negative, untreated early breast cancer (ER+/HER2– eBC): Interim analysis of the randomised, open-label, phase II coopERA BC study","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Anastrozole; Medicine; Palbociclib; Gynecology; Breast cancer; Interim analysis; Oncology; Internal medicine; Letrozole; HER2 negative; Cancer; Tamoxifen; Metastatic breast cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007000038,0.0006070808,0.002707729,0.0004102616,0.0001898696,0.0000387065,0.0006837357,0.0002180532,0.001332146],"category_scores_gemma":[0.0001341389,0.0004298078,0.0001468242,0.002645602,0.000737923,0.0003399477,0.0004193012,0.0005535758,0.000003676965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004494027,"about_ca_system_score_gemma":0.001642411,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008085876,"about_ca_topic_score_gemma":0.008298001,"domain_scores_codex":[0.9951906,0.001072725,0.00131799,0.0009293685,0.0005838316,0.000905535],"domain_scores_gemma":[0.995757,0.0003754162,0.0009290779,0.0008859661,0.001718326,0.0003341955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3897831,0.03527281,0.129777,0.0001438349,0.03021021,0.001086009,0.0278867,0.00133836,0.2507319,0.0000502543,0.0002507862,0.133469],"study_design_scores_gemma":[0.2526017,0.08130139,0.5780163,0.0008922659,0.003887436,0.0002341143,0.01430245,0.0002398107,0.0660727,0.00004013128,0.001482815,0.0009288044],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898618,0.000419399,0.00003496065,0.005686365,0.0001237673,0.002345251,0.001179831,0.0000336411,0.0003149367],"genre_scores_gemma":[0.9965528,0.0002684716,0.0004536032,0.001460205,0.00006823347,0.0005782215,0.0001352858,0.0000815228,0.0004016688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4482394,"threshold_uncertainty_score":0.9998153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03973618394100709,"score_gpt":0.3796332815891039,"score_spread":0.3398970976480968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}