{"id":"W3201907175","doi":"10.1016/j.annonc.2021.08.2086","title":"LBA14 Neoadjuvant giredestrant (GDC-9545) + palbociclib (palbo) vs anastrozole (A) + palbo in post-menopausal women with oestrogen receptor-positive, HER2-negative, untreated early breast cancer (ER+/HER2– eBC): Interim analysis of the randomised, open-label, phase II coopERA BC study","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Anastrozole; Medicine; Palbociclib; Gynecology; Breast cancer; Interim analysis; Oncology; Internal medicine; Letrozole; HER2 negative; Cancer; Tamoxifen; Metastatic breast cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001815607,0.0014214,0.002391762,0.0005016546,0.000297314,0.001230144,0.001160801,0.001197117,0.007910382],"category_scores_gemma":[0.001482578,0.0005858796,0.001990001,0.0004848426,0.0009497333,0.001092503,0.0004894147,0.003187255,0.001626521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001200631,"about_ca_system_score_gemma":0.00171226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003138832,"about_ca_topic_score_gemma":0.00754792,"domain_scores_codex":[0.9993669,0.0003452458,0.00002715865,0.00007465577,0.00005048346,0.0001354718],"domain_scores_gemma":[0.9991618,0.0002167969,0.000158308,0.00008337209,0.00004335112,0.0003364067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9531675,0.006007849,0.0009910092,0.0003296565,0.0008186307,0.00003105141,0.00004594948,0.000801953,0.002882688,0.0001418639,0.001871793,0.03291005],"study_design_scores_gemma":[0.8020455,0.1830092,0.008348762,0.0001009304,0.001222714,0.00009054918,0.0000833507,0.001028241,0.001057607,0.0003589889,0.002621731,0.00003238776],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833919,0.004895464,0.0005019468,0.0008730604,0.0004134611,0.001936258,0.003128806,0.0001969515,0.004662227],"genre_scores_gemma":[0.9754727,0.003565639,0.001553809,0.001452929,0.0002919782,0.002670998,0.006637402,0.00009098336,0.008263501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007910382,"threshold_uncertainty_score":0.02646285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03973618394100709,"score_gpt":0.3796332815891039,"score_spread":0.3398970976480968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}