{"id":"W3201943516","doi":"10.3390/curroncol28050326","title":"Frontline Treatment of the Young, Fit Patient with CLL: A Canadian Perspective","year":2021,"lang":"en","type":"review","venue":"Current Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; CancerCare Manitoba; McMaster University; University of Manitoba; Joseph Brant Hospital; Memorial University of Newfoundland","funders":"Janssen Canada","keywords":"Ibrutinib; Medicine; Fludarabine; Rituximab; Chemoimmunotherapy; Population; Chronic lymphocytic leukemia; Internal medicine; Oncology; Cyclophosphamide; Intensive care medicine; Leukemia; Chemotherapy; Lymphoma; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001005614,0.0005319486,0.001083229,0.002268106,0.0006756703,0.001357052,0.001145539,0.001451081,0.003615706],"category_scores_gemma":[0.002135148,0.0001742535,0.0006776116,0.002957996,0.0006459549,0.0009445524,0.0004983506,0.002109822,0.0006999549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007495213,"about_ca_system_score_gemma":0.01474612,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.2746734,"about_ca_topic_score_gemma":0.4652514,"domain_scores_codex":[0.999567,0.00007072358,0.0000410764,0.00004427356,0.0002033209,0.00007367475],"domain_scores_gemma":[0.9986241,0.0002935253,0.0001081526,0.00001564366,0.0008048828,0.0001537499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001862233,0.00004567061,0.0004881097,0.02017208,0.0001334092,0.0004125681,0.0002179621,0.000262942,0.000502686,0.004236149,0.1091538,0.8641884],"study_design_scores_gemma":[0.00005252081,0.00005101065,0.002183444,0.01889037,0.0002591441,0.001315174,0.0001882362,0.00007315899,0.0001131711,0.0008530763,0.9759945,0.00002626207],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008769953,0.9966543,0.00002124396,0.001708023,0.0001871095,0.000002653856,0.00001942878,0.000002338021,0.001317255],"genre_scores_gemma":[0.00119773,0.9972857,0.00007779447,0.0008943686,0.0001517447,0.000002402985,0.00002948521,9.394307e-7,0.0003598765],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7253266,"threshold_uncertainty_score":0.5461493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2151939405936631,"score_gpt":0.4829079823001927,"score_spread":0.2677140417065296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}