{"id":"W3201943516","doi":"10.3390/curroncol28050326","title":"Frontline Treatment of the Young, Fit Patient with CLL: A Canadian Perspective","year":2021,"lang":"en","type":"review","venue":"Current Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. John’s Health Sciences Centre; CancerCare Manitoba; McMaster University; University of Manitoba; Joseph Brant Hospital; Memorial University of Newfoundland","funders":"Janssen Canada","keywords":"Ibrutinib; Medicine; Fludarabine; Rituximab; Chemoimmunotherapy; Population; Chronic lymphocytic leukemia; Internal medicine; Oncology; Cyclophosphamide; Intensive care medicine; Leukemia; Chemotherapy; Lymphoma; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021679,0.0004199818,0.002342851,0.0002341439,0.0000781523,0.000009230684,0.0002374503,0.0003341149,0.0003716593],"category_scores_gemma":[0.0001797,0.0002163648,0.0006058175,0.0004891268,0.0003166017,0.00001438769,0.00010197,0.0004706364,0.00004086566],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.1417074,"about_ca_system_score_gemma":0.1263466,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08257417,"about_ca_topic_score_gemma":0.1672621,"domain_scores_codex":[0.9975279,0.0003674513,0.0005393753,0.0005753101,0.0004249913,0.0005649547],"domain_scores_gemma":[0.9976541,0.0002131335,0.0003359127,0.0009027605,0.0004909784,0.0004030824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005254772,0.001122323,0.00004678746,0.002807156,0.0008696165,0.000981892,0.001488294,8.135602e-7,3.782725e-8,0.0002265995,0.004666892,0.9877371],"study_design_scores_gemma":[0.004643965,0.002684478,0.000008502517,0.007444174,0.002065406,0.002711433,0.0004824537,0.00002985278,0.000001507163,0.000005297073,0.979746,0.0001769715],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002047676,0.9911358,0.000001437061,0.0002711717,0.001020757,0.002425955,0.0002166712,0.00001270351,0.00471072],"genre_scores_gemma":[0.0003329596,0.9978128,0.00005157128,0.00002230962,0.0003548142,0.0004459081,0.0001697534,0.00005718941,0.0007527031],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9875601,"threshold_uncertainty_score":0.923535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2151939405936631,"score_gpt":0.4829079823001927,"score_spread":0.2677140417065296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}