{"id":"W3201981182","doi":"10.1016/s1470-2045(21)00402-2","title":"Apalutamide plus abiraterone acetate and prednisone versus placebo plus abiraterone and prednisone in metastatic, castration-resistant prostate cancer (ACIS): a randomised, placebo-controlled, double-blind, multinational, phase 3 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Research and Development; National Cancer Institute","keywords":"Abiraterone acetate; Prednisone; Prostate cancer; Medicine; Placebo; Androgen deprivation therapy; Internal medicine; Oncology; Urology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001948806,0.002086102,0.003808217,0.0007788404,0.0005834489,0.001333829,0.001338517,0.002200346,0.005864248],"category_scores_gemma":[0.002315386,0.0009559327,0.002266139,0.0007594096,0.001930593,0.001360396,0.0005205721,0.003605362,0.0011104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007485189,"about_ca_system_score_gemma":0.00127127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001937215,"about_ca_topic_score_gemma":0.00329631,"domain_scores_codex":[0.9991661,0.0004543292,0.00005853684,0.0001394061,0.00007179673,0.0001098798],"domain_scores_gemma":[0.9984031,0.000531636,0.0003119383,0.0001185272,0.00008241677,0.0005524186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9891698,0.00352967,0.0001243056,0.0002850236,0.0004545838,0.00001439794,0.00003079814,0.0001196322,0.001318716,0.00003604997,0.0001705188,0.004746615],"study_design_scores_gemma":[0.9358589,0.06242117,0.0007306935,0.00001629948,0.0003062788,0.00001704841,0.00001826919,0.0001602334,0.0002007929,0.00008324367,0.0001746756,0.00001242967],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885343,0.00492764,0.0005694086,0.0005323379,0.0007169356,0.002375735,0.0006648059,0.0001521883,0.001526642],"genre_scores_gemma":[0.9889224,0.003084976,0.001149883,0.0006572679,0.0006486206,0.002069626,0.0004932648,0.00003253043,0.002941499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005864248,"threshold_uncertainty_score":0.01961792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085101239317499,"score_gpt":0.4188935083107546,"score_spread":0.3103833843790046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}