{"id":"W3201981182","doi":"10.1016/s1470-2045(21)00402-2","title":"Apalutamide plus abiraterone acetate and prednisone versus placebo plus abiraterone and prednisone in metastatic, castration-resistant prostate cancer (ACIS): a randomised, placebo-controlled, double-blind, multinational, phase 3 study","year":2021,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Janssen Research and Development; National Cancer Institute","keywords":"Abiraterone acetate; Prednisone; Prostate cancer; Medicine; Placebo; Androgen deprivation therapy; Internal medicine; Oncology; Urology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001985839,0.0004770556,0.001890646,0.0002195206,0.0003150138,0.0001481216,0.0001815215,0.0001434437,0.0001635745],"category_scores_gemma":[0.0002164615,0.0003210983,0.0000895949,0.0004088689,0.0004729209,0.0002359698,0.0002014695,0.0005936443,0.00001241037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009200612,"about_ca_system_score_gemma":0.001699949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006236053,"about_ca_topic_score_gemma":0.0056461,"domain_scores_codex":[0.9958997,0.000982314,0.0008819923,0.0008231335,0.0005617132,0.0008511989],"domain_scores_gemma":[0.9974666,0.001096065,0.0003387323,0.0004869979,0.0003442176,0.0002673596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9673977,0.00152956,0.0008961026,0.0002825073,0.001603584,0.001383672,0.01058671,0.0006784553,0.01150709,0.00008193561,0.00024648,0.003806182],"study_design_scores_gemma":[0.9785385,0.003926834,0.001965536,0.0001281828,0.001018734,0.0001382752,0.005662021,0.005183532,0.00223031,0.00007615587,0.000811963,0.0003199745],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721385,0.008195703,0.00003333431,0.007989517,0.0003060103,0.01048412,0.000178146,0.00006564899,0.0006090459],"genre_scores_gemma":[0.9856231,0.003760232,0.0006359037,0.0002223487,0.0002680038,0.005837725,0.000172096,0.00005853481,0.003422047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01348464,"threshold_uncertainty_score":0.9999241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085101239317499,"score_gpt":0.4188935083107546,"score_spread":0.3103833843790046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}