{"id":"W3202015161","doi":"10.1101/2021.10.04.462976","title":"Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite <i>Toxoplasma gondii</i>","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Université de Genève; Universiteit Stellenbosch; Institute of Genetics and Genomics of Geneva; European Commission","keywords":"Toxoplasma gondii; Biology; Protozoan parasite; Parasite hosting; Apicomplexa; Biosynthesis; Pathogen; Protozoa; Chronic infection; Gene; Coenzyme A; Enzyme; Microbiology; Biochemistry; Genetics; Immunology; Plasmodium falciparum; Immune system; Malaria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001188472,0.000287577,0.0002505759,0.0001529796,0.0001864799,0.0004279216,0.0001187492,0.000396058,0.0016369],"category_scores_gemma":[0.0001551715,0.0001411962,0.0001638759,0.0001235738,0.0002878293,0.0002139075,0.0003035424,0.0004083547,0.000669265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003024744,"about_ca_system_score_gemma":0.0003258385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006944207,"about_ca_topic_score_gemma":0.001441405,"domain_scores_codex":[0.9998882,0.00001145564,0.00000853079,0.00003291311,0.00002823788,0.00003054719],"domain_scores_gemma":[0.9999088,0.00001003795,0.00003185502,0.000008011137,0.0000145494,0.00002682869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002096726,0.000009357632,0.0008312995,0.00006791187,0.00000525635,0.000208952,0.00002409379,0.00002494522,0.9968559,0.0001719389,0.0002488708,0.001341934],"study_design_scores_gemma":[0.00004122772,0.0002972339,0.0555821,0.00004877318,0.00003619403,0.002266965,0.0002442085,0.001548685,0.9244481,0.0008490095,0.01462266,0.00001481671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803477,0.004707071,0.006300979,0.00112508,0.0002123907,0.00003250756,0.001688839,0.0002699108,0.005315524],"genre_scores_gemma":[0.9891054,0.001474059,0.002920044,0.0001577109,0.00003443962,0.00002012938,0.001406058,0.00008249857,0.004799628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016369,"threshold_uncertainty_score":0.005475938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02404993545726372,"score_gpt":0.2575476876896915,"score_spread":0.2334977522324278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}