{"id":"W3202022834","doi":"10.1016/s0378-4274(21)00600-7","title":"Quantitative dose response modelling of historical ToxTracker data to evaluate in vitro genotoxicity and mode of action","year":2021,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Genotoxicity; Mode of action; Pharmacology; Toxicology; Medicine; Biology; Internal medicine; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001299037,0.0009153037,0.0005715442,0.0007233649,0.0001706094,0.0008264226,0.0008884701,0.0009059297,0.003191592],"category_scores_gemma":[0.00249765,0.0003410576,0.000991924,0.00075574,0.0001964672,0.0005628156,0.0002803523,0.0007927498,0.001337554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001070707,"about_ca_system_score_gemma":0.0006408011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006514865,"about_ca_topic_score_gemma":0.004744752,"domain_scores_codex":[0.9994186,0.0001596519,0.00003842386,0.0001539658,0.0001891164,0.00004017258],"domain_scores_gemma":[0.9985258,0.0007530488,0.0001710422,0.0002011633,0.0003266507,0.0000222896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000899169,0.0002600127,0.005804783,0.0006893734,0.0001843622,0.0001045702,0.0001299556,0.777576,0.1818803,0.001397882,0.001588843,0.02948473],"study_design_scores_gemma":[0.0000405639,0.0009099583,0.005509634,0.00003640676,0.0001224502,0.0001729953,0.00006322702,0.7981358,0.189231,0.0009806415,0.004737694,0.0000596992],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6145044,0.0022509,0.3502189,0.0004656437,0.0001070698,0.0004381795,0.01596972,0.004295474,0.01174965],"genre_scores_gemma":[0.949738,0.0009651241,0.03440671,0.0001494558,0.000009443552,0.0003134976,0.006898599,0.0003476123,0.007171637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006514865,"threshold_uncertainty_score":0.01295394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1159963972238613,"score_gpt":0.3643782086676198,"score_spread":0.2483818114437585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}