{"id":"W3202031131","doi":"10.1038/s41586-021-03990-6","title":"A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Dengue virus; Dengue fever; Virology; NS3; Serotype; Virus; Antibody-dependent enhancement; Viral replication; Biology; Flavivirus; Hepatitis C virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522319,0.0004288449,0.0003508454,0.0001207672,0.0002295737,0.0002879578,0.0003525372,0.0003187605,0.003457854],"category_scores_gemma":[0.00006613976,0.0001324823,0.0002419743,0.00009071464,0.0001251628,0.0001985701,0.0002116039,0.0007345277,0.0007207573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003397559,"about_ca_system_score_gemma":0.0002780596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007938687,"about_ca_topic_score_gemma":0.001991867,"domain_scores_codex":[0.9999424,0.000007290796,0.000002398007,0.00001104641,0.00001350894,0.00002341924],"domain_scores_gemma":[0.9999821,0.000002454419,0.000002988975,0.000001252303,0.000003338159,0.000007826072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009163159,0.000257451,0.0003430933,0.0001931799,0.00008448222,0.0001451216,0.00001981423,0.0007539627,0.9592183,0.001201694,0.003367052,0.03349958],"study_design_scores_gemma":[0.0007890061,0.00250422,0.004131209,0.00004483877,0.0001277566,0.001299492,0.00004742064,0.00814639,0.9169766,0.0005006949,0.06539828,0.0000340229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.913689,0.02993041,0.02177983,0.001449459,0.0007344844,0.0003854803,0.001145665,0.0006845383,0.03020118],"genre_scores_gemma":[0.9703473,0.008018327,0.007044341,0.000576467,0.00005203502,0.0001038508,0.001044076,0.00003508537,0.0127784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003457854,"threshold_uncertainty_score":0.01156765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006487310520980637,"score_gpt":0.2805936180397967,"score_spread":0.274106307518816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}