{"id":"W3202031131","doi":"10.1038/s41586-021-03990-6","title":"A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Dengue virus; Dengue fever; Virology; NS3; Serotype; Virus; Antibody-dependent enhancement; Viral replication; Biology; Flavivirus; Hepatitis C virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058606,0.0001118739,0.000156057,0.00002449114,0.0001038132,0.00004722504,0.00007506308,0.0004000909,0.0004642038],"category_scores_gemma":[0.0004735954,0.00007238193,0.0001414246,0.000180369,0.00001570264,0.00006834777,0.00004415554,0.001584734,0.00007319317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004330787,"about_ca_system_score_gemma":0.0001109278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002980027,"about_ca_topic_score_gemma":0.00005751885,"domain_scores_codex":[0.9991533,0.00005573468,0.0001469974,0.0002262181,0.0002389279,0.0001788689],"domain_scores_gemma":[0.9993203,0.00007696723,0.00005917675,0.0002664608,0.0002002086,0.0000769263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001508586,0.000809431,0.02004813,0.0003508217,0.0006012539,0.001247189,0.001104817,0.00002174119,0.4889247,0.002893954,0.3562056,0.1262838],"study_design_scores_gemma":[0.002440117,0.0001309049,0.04980035,0.0003111084,0.0004589999,0.0001379619,0.001983993,0.001055985,0.0673301,0.0002519425,0.8758104,0.0002880806],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543993,0.02556563,0.00005094898,0.01433822,0.001807798,0.0003720103,0.00002448168,0.00009660838,0.003344937],"genre_scores_gemma":[0.9888098,0.0001092812,0.00008509407,0.007957834,0.001672593,0.00002337886,0.00007179775,0.00001839277,0.001251841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5196048,"threshold_uncertainty_score":0.6884968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006487310520980637,"score_gpt":0.2805936180397967,"score_spread":0.274106307518816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}