{"id":"W3202083716","doi":"10.1016/j.cbi.2021.109688","title":"1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity","year":2021,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Universidade Federal de Juiz de Fora; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Centre for Blood Research, University of British Columbia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Plasmodium berghei; In silico; In vivo; Antimalarial Agent; Plasmodium falciparum; Docking (animal); Pharmacology; Cytotoxicity; Chloroquine; Hemolysis; Chemistry; In vitro; Biochemistry; Biology; Malaria; Medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001274739,0.0002734801,0.0003364184,0.0003208854,0.0002157074,0.0001657496,0.0003356486,0.0002420992,0.001487913],"category_scores_gemma":[0.0001530667,0.00008999537,0.0002388342,0.000473404,0.0001284628,0.0001366509,0.0001175026,0.0004068011,0.0003812361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003243038,"about_ca_system_score_gemma":0.0003083933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00370533,"about_ca_topic_score_gemma":0.006969176,"domain_scores_codex":[0.9999458,0.00001177786,0.000003614553,0.000007046894,0.00001259066,0.00001919864],"domain_scores_gemma":[0.9999626,0.000004829149,0.000007150768,0.000005156383,0.00001117175,0.0000091451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005436238,0.0002176154,0.000523788,0.0002651284,0.00002947982,0.0003586007,0.00009262723,0.001913027,0.9764755,0.0004326439,0.0006639006,0.01848413],"study_design_scores_gemma":[0.0001873117,0.004919326,0.009980159,0.0000459842,0.0001637382,0.001312825,0.00009560679,0.004065447,0.9612125,0.0001575296,0.01781056,0.00004897916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725815,0.01461252,0.004677446,0.0003266289,0.00005769717,0.000162421,0.001254311,0.0002087604,0.006118604],"genre_scores_gemma":[0.9813663,0.008649515,0.003715099,0.00007752953,0.0000138791,0.0000561737,0.001354267,0.00002036357,0.00474695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00370533,"threshold_uncertainty_score":0.007367492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359017070248488,"score_gpt":0.3138602364129706,"score_spread":0.2802700657104857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}