{"id":"W3202083716","doi":"10.1016/j.cbi.2021.109688","title":"1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity","year":2021,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Universidade Federal de Juiz de Fora; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Centre for Blood Research, University of British Columbia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Plasmodium berghei; In silico; In vivo; Antimalarial Agent; Plasmodium falciparum; Docking (animal); Pharmacology; Cytotoxicity; Chloroquine; Hemolysis; Chemistry; In vitro; Biochemistry; Biology; Malaria; Medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001126122,0.0001934761,0.0005278462,0.0001790706,0.00009757428,0.00003395049,0.00005199653,0.0001420399,0.001467442],"category_scores_gemma":[0.0007045043,0.0001491779,0.0001908947,0.0006836243,0.00009813879,0.0001133096,0.00009918553,0.0003201521,0.00001696745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645236,"about_ca_system_score_gemma":0.00006304654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002559416,"about_ca_topic_score_gemma":0.00007809223,"domain_scores_codex":[0.9988483,0.0000842602,0.0002661126,0.0004561053,0.0001019408,0.0002432725],"domain_scores_gemma":[0.9989751,0.0005412325,0.00008507702,0.0001987824,0.00007705003,0.0001227415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002350349,0.0008142698,0.2849242,0.00001351159,0.0008167319,0.0001293244,0.0001628038,0.000003513805,0.711926,0.00004014948,0.0002783858,0.0006559493],"study_design_scores_gemma":[0.0005981163,0.0000183835,0.1520638,0.00005037815,0.0003359213,0.00005544587,0.0002141232,0.0002691258,0.8442369,0.0000414468,0.001961712,0.0001545922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935371,0.00006282274,0.0003196442,0.001630895,0.00006327061,0.0001610858,0.00003238691,0.00005631652,0.004136536],"genre_scores_gemma":[0.9969161,0.0001868011,0.001287281,0.0001101666,0.00007750942,0.00007332321,0.00005895881,0.000007498335,0.001282418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1328604,"threshold_uncertainty_score":0.9994454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03359017070248488,"score_gpt":0.3138602364129706,"score_spread":0.2802700657104857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}