{"id":"W3202168364","doi":"10.1186/s13195-021-00906-4","title":"BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Minor allele frequency; Single-nucleotide polymorphism; Cognitive decline; Biomarker; Alzheimer's disease; Oncology; Allele; Internal medicine; Medicine; Genetic association; Disease; Dementia; Genetics; Genotype; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007807126,0.0004427637,0.0003834347,0.00115757,0.0003060114,0.0004593009,0.0004305368,0.0005092929,0.002239752],"category_scores_gemma":[0.002467181,0.0002475893,0.0004988163,0.000861077,0.0002580817,0.0002455623,0.0003990131,0.0006812504,0.0002720514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001721016,"about_ca_system_score_gemma":0.0001349948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002910775,"about_ca_topic_score_gemma":0.001712034,"domain_scores_codex":[0.9997085,0.00007536729,0.00003085331,0.0001039768,0.00005516682,0.00002613257],"domain_scores_gemma":[0.9981976,0.0003254326,0.0009121649,0.0001481412,0.00019601,0.0002206566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001513975,0.00005764773,0.9861486,0.00003207655,0.0003721279,0.0001475189,0.00007709492,0.0001795006,0.007385129,0.00005488256,0.0003096203,0.003721774],"study_design_scores_gemma":[0.00001256132,0.00007420457,0.9987632,0.000005494119,0.00005786364,0.0002077828,0.00002130055,0.000390791,0.0002880771,0.00006550816,0.0001091542,0.000004088458],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984571,0.0004199829,0.0003221374,0.00006301364,0.0000118481,0.000005490785,0.000462143,0.000014856,0.0002434603],"genre_scores_gemma":[0.9987997,0.00008939546,0.0004115224,0.00002684413,0.00001750788,0.000009248981,0.0003570125,0.000007021265,0.0002817702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002910775,"threshold_uncertainty_score":0.007492781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1264876927375488,"score_gpt":0.4237787673247108,"score_spread":0.297291074587162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}