{"id":"W3202168364","doi":"10.1186/s13195-021-00906-4","title":"BMI1 is associated with CSF amyloid-β and rates of cognitive decline in Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; U.S. National Library of Medicine; IXICO; National Institute of General Medical Sciences; H. Lundbeck A/S; Servier; Eisai; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Minor allele frequency; Single-nucleotide polymorphism; Cognitive decline; Biomarker; Alzheimer's disease; Oncology; Allele; Internal medicine; Medicine; Genetic association; Disease; Dementia; Genetics; Genotype; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009439331,0.0003484846,0.0006811838,0.0004461111,0.0001937381,0.00008181825,0.0001801402,0.0001363528,0.0007153668],"category_scores_gemma":[0.0006250569,0.0002663574,0.0001449709,0.001473759,0.0008523628,0.0002505562,0.0002036944,0.0006246803,0.0000523221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005386159,"about_ca_system_score_gemma":0.001673626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004451278,"about_ca_topic_score_gemma":0.000161631,"domain_scores_codex":[0.9953013,0.0007836611,0.0004398733,0.0007877537,0.001680079,0.001007334],"domain_scores_gemma":[0.9951594,0.001365719,0.0001029907,0.0005468135,0.001785876,0.001039184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01646282,0.007122888,0.8633168,0.00004232477,0.0624127,0.005860154,0.001416149,0.000001303409,0.0007502708,0.0001349996,0.001467388,0.04101221],"study_design_scores_gemma":[0.020238,0.002522177,0.9294402,0.001057045,0.001818483,0.0000420555,0.001087951,0.0002338927,0.04124895,0.00125026,0.000596147,0.0004648518],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7691016,0.2252152,0.000002762655,0.003265892,0.00001753658,0.001371213,0.000209404,0.00003195778,0.0007844134],"genre_scores_gemma":[0.9855562,0.01274633,0.00008176288,0.000739509,0.0000582001,0.0002498014,0.0004076241,0.00007678723,0.00008381383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2164546,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1264876927375488,"score_gpt":0.4237787673247108,"score_spread":0.297291074587162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}