{"id":"W3202197007","doi":"10.3389/fonc.2021.714550","title":"Transcriptomic Correlates of Immunologic Activation in Head and Neck and Cervical Cancer","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Head and neck squamous-cell carcinoma; Medicine; Immune system; Oncology; Cancer; Effector; Lung cancer; Immunotherapy; Cancer research; Transcriptome; Tumor-infiltrating lymphocytes; Internal medicine; Head and neck cancer; Immunology; Gene; Gene expression; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119761,0.0001256899,0.0002026485,0.0007994141,0.0002020433,0.0003522025,0.00008677376,0.0001997312,0.001092523],"category_scores_gemma":[0.0003248364,0.00006271462,0.0001596595,0.001060454,0.0001605498,0.0001009046,0.000286357,0.0001938272,0.0001979761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258836,"about_ca_system_score_gemma":0.0002337617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001653071,"about_ca_topic_score_gemma":0.003302408,"domain_scores_codex":[0.9998685,0.00001363028,0.00001004383,0.00003948095,0.00003008687,0.00003828859],"domain_scores_gemma":[0.9998314,0.00003158645,0.00006036287,0.0000122575,0.00003692418,0.00002747311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001171641,0.00009155606,0.5680912,0.0002343331,0.0001469581,0.0003431556,0.0003015904,0.0004143617,0.4109564,0.0001688153,0.0007572793,0.01732269],"study_design_scores_gemma":[0.000005498379,0.0001295765,0.9883479,0.00001197094,0.00005618593,0.0002986622,0.0002936547,0.0005328653,0.008801918,0.00009823543,0.001416267,0.000007253267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994362,0.0008748294,0.0002574695,0.00004735877,0.000009024539,0.00002036366,0.003553617,0.00001241082,0.0008629506],"genre_scores_gemma":[0.9945644,0.0004347024,0.0006192501,0.00005387657,0.000008411766,0.00005517569,0.00353133,0.000005199513,0.0007276023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001653071,"threshold_uncertainty_score":0.003654838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01573851085939493,"score_gpt":0.2982460248582651,"score_spread":0.2825075139988702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}