{"id":"W3202200735","doi":"10.1002/mds.28808","title":"Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score","year":2021,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Helse Sør-Øst RHF; Horizon 2020 Framework Programme; National Institutes of Health; Nasjonalforeningen for Folkehelsen; Norges Forskningsråd; Parkinson's UK; Wellcome Trust","keywords":"Hazard ratio; Proportional hazards model; Confidence interval; Disease; Polygenic risk score; Medicine; Decile; Internal medicine; Statistics; Biology; Genetics; Single-nucleotide polymorphism; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007283074,0.0002289136,0.000272963,0.00007069927,0.00009551674,0.00002690219,0.00009289767,0.00005502605,0.0004975018],"category_scores_gemma":[0.00004368228,0.0002196218,0.0001985032,0.0001828175,0.0000524674,0.00005325783,0.00004514575,0.00009254239,0.00002944057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021728,"about_ca_system_score_gemma":0.0002015387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001672175,"about_ca_topic_score_gemma":0.0001991129,"domain_scores_codex":[0.9982695,0.00007698841,0.0003312217,0.0005123446,0.0005183732,0.0002915538],"domain_scores_gemma":[0.998831,0.00001771478,0.000173321,0.0005842154,0.00006662164,0.0003271037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004858233,0.004056064,0.9198568,0.0002500195,0.0008280064,0.0002810285,0.0001605421,0.0001135596,0.01833544,0.0004530868,0.00501874,0.05016085],"study_design_scores_gemma":[0.003282451,0.0002267289,0.9674899,0.00007266078,0.0007642563,4.194845e-7,0.0003120884,0.0003437956,0.01027976,0.01166056,0.005316172,0.000251227],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894336,0.005974927,0.001937218,0.0007973654,0.0001376897,0.0006220119,0.000367709,0.00004745898,0.0006819697],"genre_scores_gemma":[0.9945042,0.002404803,0.000552575,0.0007788914,0.00002619084,0.0001267122,0.0004293091,0.00003415994,0.001143207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04990962,"threshold_uncertainty_score":0.8955916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113405786625521,"score_gpt":0.2415125867516891,"score_spread":0.230172008089137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}