{"id":"W3202200735","doi":"10.1002/mds.28808","title":"Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score","year":2021,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Helse Sør-Øst RHF; Horizon 2020 Framework Programme; National Institutes of Health; Nasjonalforeningen for Folkehelsen; Norges Forskningsråd; Parkinson's UK; Wellcome Trust","keywords":"Hazard ratio; Proportional hazards model; Confidence interval; Disease; Polygenic risk score; Medicine; Decile; Internal medicine; Statistics; Biology; Genetics; Single-nucleotide polymorphism; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004539114,0.0005074092,0.0003862594,0.0009318161,0.0002295553,0.0007002345,0.0003766015,0.0004185878,0.001897246],"category_scores_gemma":[0.008621309,0.0001440518,0.001060846,0.0006903898,0.0004681473,0.0003494711,0.0004271755,0.0006056077,0.0002002006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695479,"about_ca_system_score_gemma":0.000548412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004978022,"about_ca_topic_score_gemma":0.003594945,"domain_scores_codex":[0.9987853,0.0008009878,0.00004386525,0.0002171547,0.00008390201,0.00006883909],"domain_scores_gemma":[0.9944485,0.004063326,0.0006773227,0.0004445707,0.000195116,0.000171063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006360692,0.0000687479,0.9319592,0.00003516289,0.001131281,0.0002152894,0.0001289755,0.03170049,0.001279032,0.001863893,0.0005368614,0.03044498],"study_design_scores_gemma":[0.00008667273,0.0004161973,0.6496493,0.00002739154,0.0006034857,0.0004422242,0.00007191043,0.3376378,0.0007815483,0.009363342,0.0008656299,0.00005456177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562522,0.0003760582,0.04156739,0.0002884529,0.00002497141,0.00004498413,0.0007426641,0.00008320034,0.0006200843],"genre_scores_gemma":[0.9963155,0.00008854037,0.003053335,0.000021874,0.00001277025,0.0000168176,0.0002949267,0.000007964038,0.0001882707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004978022,"threshold_uncertainty_score":0.02400541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113405786625521,"score_gpt":0.2415125867516891,"score_spread":0.230172008089137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}