{"id":"W3202223590","doi":"10.5451/unibas-ep79908","title":"Modification of tau pathology by yeast prion seeding and tau oligomer expression","year":2020,"lang":"en","type":"article","venue":"edoc (University of Basel)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Mach-Gaensslen Foundation of Canada; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Progressive supranuclear palsy; Corticobasal degeneration; Fatal familial insomnia; Tauopathy; Frontotemporal dementia; Tau protein; Neuroscience; Tau pathology; Neurodegeneration; Fibril; Parkinsonism; Population; Biology; Olfactory bulb; Disease; Dementia; Pathology; Medicine; Prion protein; Alzheimer's disease; Genetics; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145385,0.0002851879,0.0001381429,0.0001425853,0.00009181686,0.0002740813,0.0001291632,0.0002243798,0.0005423074],"category_scores_gemma":[0.0001617235,0.0001034221,0.0002019077,0.0001368894,0.000222596,0.0001347746,0.0001826715,0.0004519963,0.0001982496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584081,"about_ca_system_score_gemma":0.00009846397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004613092,"about_ca_topic_score_gemma":0.0004753289,"domain_scores_codex":[0.9998872,0.00002563132,0.00001407615,0.00002400924,0.00002948186,0.00001960549],"domain_scores_gemma":[0.9998747,0.00002304728,0.00004175879,0.00002432691,0.00001603615,0.00002013685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005902239,0.00001838814,0.0001124408,0.00001706815,0.00000229854,0.00003053524,0.0000110304,0.00003001224,0.9990983,0.00004962965,0.00001379769,0.0005574055],"study_design_scores_gemma":[0.000007607986,0.000275209,0.003286757,0.000005524028,0.000008897302,0.0001659923,0.00002588844,0.0007026542,0.9944614,0.00007418319,0.0009820204,0.000003904073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932866,0.001095862,0.00417253,0.00006209055,0.00002477754,0.00002745821,0.000246626,0.00007063541,0.001013416],"genre_scores_gemma":[0.9943855,0.0006605564,0.003127461,0.00002753981,0.000006973376,0.00002198953,0.0003952041,0.00002157571,0.001353266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005423074,"threshold_uncertainty_score":0.001814246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117150629133976,"score_gpt":0.2052013191620492,"score_spread":0.1940298128707095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}