{"id":"W3202223590","doi":"10.5451/unibas-ep79908","title":"Modification of tau pathology by yeast prion seeding and tau oligomer expression","year":2020,"lang":"en","type":"article","venue":"edoc (University of Basel)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Mach-Gaensslen Foundation of Canada; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Progressive supranuclear palsy; Corticobasal degeneration; Fatal familial insomnia; Tauopathy; Frontotemporal dementia; Tau protein; Neuroscience; Tau pathology; Neurodegeneration; Fibril; Parkinsonism; Population; Biology; Olfactory bulb; Disease; Dementia; Pathology; Medicine; Prion protein; Alzheimer's disease; Genetics; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005051703,0.00005552448,0.00008995444,0.00002034512,0.0000499826,0.000002551213,0.00009095003,0.00007114033,0.00004431925],"category_scores_gemma":[0.00002534599,0.0000670782,0.00003975918,0.00004884401,0.00006308962,0.000007916672,0.0001029944,0.00003475634,0.000001648789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003956665,"about_ca_system_score_gemma":0.00001791738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002312739,"about_ca_topic_score_gemma":0.000001106314,"domain_scores_codex":[0.9995962,0.00003438097,0.00006181375,0.0001738724,0.00006076292,0.00007299353],"domain_scores_gemma":[0.9996992,0.000004535488,0.00008972627,0.00009657538,0.00003797308,0.00007194426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009253225,0.00001982571,0.001230202,0.00004106635,0.000008551814,0.000001676797,0.0002558079,0.00001287254,0.9874704,0.00002316047,0.002400957,0.008442971],"study_design_scores_gemma":[0.001021013,0.0003048862,0.006663944,0.0000499794,0.00004441768,0.00000385048,0.00215602,0.0008371782,0.9643636,0.00003771306,0.02431526,0.0002021855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886105,0.001518353,0.009257759,0.0003835424,0.00001792184,0.00008031655,0.00005641182,0.000006082693,0.00006909818],"genre_scores_gemma":[0.9977037,0.0009306018,0.001165523,0.00005522061,0.00002835602,1.995691e-7,0.00007366846,0.000004625614,0.00003807132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02310683,"threshold_uncertainty_score":0.273537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117150629133976,"score_gpt":0.2052013191620492,"score_spread":0.1940298128707095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}