{"id":"W3202229272","doi":"10.3390/brainsci11101282","title":"Pro-Inflammatory Cytokines and Antibodies Induce hnRNP A1 Dysfunction in Mouse Primary Cortical Neurons","year":2021,"lang":"en","type":"article","venue":"Brain Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"University of Saskatchewan","keywords":"Neurodegeneration; Multiple sclerosis; Immune system; Ribonucleoprotein; Inflammation; Neuroscience; Neurite; Microglia; Neuroinflammation; Central nervous system; Immunology; Cytokine; Antibody; RNA-binding protein; Biology; Disease; Medicine; RNA; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004181695,0.00007191448,0.00008245473,0.00005210112,0.0001492384,0.00007025736,0.0001035432,0.00005371527,0.000005965413],"category_scores_gemma":[0.0005841819,0.00006088765,0.00002057058,0.0001593988,0.0003329453,0.00001357845,0.000146923,0.00008918012,0.000002111209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006881727,"about_ca_system_score_gemma":0.0002013443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001633127,"about_ca_topic_score_gemma":0.0001502829,"domain_scores_codex":[0.9990547,0.00009815487,0.0001186056,0.0003224322,0.0001766955,0.0002293542],"domain_scores_gemma":[0.9997036,0.00004659235,0.00002328245,0.0001184332,0.00004188088,0.00006623005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001410399,0.00001775009,0.06184556,0.00001488913,0.00000274106,0.00001824222,0.00002453084,0.00001053009,0.9356785,0.0001059285,0.0004178735,0.001849291],"study_design_scores_gemma":[0.000499145,0.0002873364,0.4449227,0.00002633339,0.000002724934,0.00006916565,0.0004340465,0.0004790291,0.5485828,0.0000954355,0.004395843,0.0002054257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973954,0.000458725,0.00006350761,0.001159668,0.00005129796,0.00007981924,0.000002642389,0.000007385888,0.0007815395],"genre_scores_gemma":[0.9969919,0.0002031341,0.0003024705,0.0005017523,0.00007155709,0.00000810806,0.000009120568,0.000004912953,0.001907016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3870958,"threshold_uncertainty_score":0.2482927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02226556015486255,"score_gpt":0.2884320627747841,"score_spread":0.2661665026199216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}