{"id":"W3202229272","doi":"10.3390/brainsci11101282","title":"Pro-Inflammatory Cytokines and Antibodies Induce hnRNP A1 Dysfunction in Mouse Primary Cortical Neurons","year":2021,"lang":"en","type":"article","venue":"Brain Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"University of Saskatchewan","keywords":"Neurodegeneration; Multiple sclerosis; Immune system; Ribonucleoprotein; Inflammation; Neuroscience; Neurite; Microglia; Neuroinflammation; Central nervous system; Immunology; Cytokine; Antibody; RNA-binding protein; Biology; Disease; Medicine; RNA; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002256232,0.0007405832,0.0004521089,0.0007670164,0.0002406892,0.0003832723,0.0003068299,0.0004652033,0.001337297],"category_scores_gemma":[0.0001197267,0.0003031147,0.0004805008,0.0003093754,0.0003692373,0.0002098119,0.0002772128,0.001017937,0.0006918658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005707399,"about_ca_system_score_gemma":0.0003604072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968384,"about_ca_topic_score_gemma":0.002938575,"domain_scores_codex":[0.9996876,0.00003446169,0.00003407557,0.00007232721,0.00008268547,0.00008884046],"domain_scores_gemma":[0.9997451,0.00003488396,0.00006906241,0.00003031401,0.00003385971,0.00008685644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009555776,0.00003186609,0.00006322582,0.00002497358,0.000006716883,0.00008937373,0.00001850018,0.00003227402,0.9993771,0.00003049951,0.00001769884,0.0002123279],"study_design_scores_gemma":[0.00002043355,0.0003561078,0.003754557,0.000009167078,0.00001994335,0.0002550521,0.00006544885,0.0003819996,0.9946127,0.00006315573,0.0004574234,0.000004065233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927726,0.001628303,0.002423245,0.0001053919,0.00006970752,0.00006272478,0.0008602921,0.0001586938,0.00191905],"genre_scores_gemma":[0.9880859,0.001745864,0.0023625,0.0001105449,0.0000152596,0.0001419006,0.0006913443,0.00005008822,0.006796692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001968384,"threshold_uncertainty_score":0.004473686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02226556015486255,"score_gpt":0.2884320627747841,"score_spread":0.2661665026199216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}