{"id":"W3202259720","doi":"10.1172/jci152386","title":"Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Cilag; National Institute of Diabetes and Digestive and Kidney Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Grifols; Junta de Castilla y León; National Center for Advancing Translational Sciences; Consejo Superior de Investigaciones Científicas; Regione Toscana; Science for Life Laboratory; Fonds Léon Fredericq; Magnus Bergvalls Stiftelse; Norges Forskningsråd; NordForsk; Vetenskapsrådet; Technische Universität München; Ministero della Salute; Fonds Erasme; Fonds De La Recherche Scientifique - FNRS; King's College London; Jewish General Hospital; Public Health Agency of Canada; Bundesministerium für Bildung und Forschung; Helsingin Yliopisto; European Commission; Cancer Research UK; Deutsche Forschungsgemeinschaft; McGill University; Dipartimenti di Eccellenza; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Ministero dell’Istruzione, dell’Università e della Ricerca; ViiV Healthcare; Humanitas University; Public Health Agency; Japan Society for the Promotion of Science; GlaxoSmithKline; Biogen; Instituto de Salud Carlos III; Waalse Gewest; Università degli Studi di Siena; Associazione Italiana per la Ricerca sul Cancro; Eli Lilly and Company","keywords":"Odds ratio; Risk factor; Respiratory failure; Allele; Case-control study; Odds; Risk of mortality; Genetic predisposition; Respiratory system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004225323,0.0008295375,0.00136198,0.00105975,0.0003892876,0.001106867,0.0006123608,0.000752399,0.001555705],"category_scores_gemma":[0.007621012,0.0004313929,0.005617311,0.001317308,0.0003782383,0.0006090065,0.00073104,0.00090027,0.0001224971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000381405,"about_ca_system_score_gemma":0.0003142851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006834932,"about_ca_topic_score_gemma":0.009483885,"domain_scores_codex":[0.9976456,0.0009642409,0.0003072565,0.0006897497,0.0002103103,0.0001828665],"domain_scores_gemma":[0.9951386,0.002762982,0.001010501,0.0006015182,0.0003159438,0.0001704142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004196135,0.00003455037,0.880828,0.002427931,0.09006873,0.0002513714,0.0001082246,0.001183137,0.000992763,0.0002937255,0.001375563,0.01823991],"study_design_scores_gemma":[0.000273953,0.0004447183,0.9217466,0.0006923569,0.07005926,0.0005645568,0.0001066426,0.0011057,0.0005317886,0.0008679638,0.003571406,0.00003502674],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7201408,0.2672019,0.003035393,0.0009893775,0.0004492929,0.00006513043,0.005099719,0.00006730584,0.002951117],"genre_scores_gemma":[0.9859502,0.01119139,0.0007693415,0.0003464046,0.0001503145,0.00003502949,0.001227459,0.00001741839,0.0003125607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006834932,"threshold_uncertainty_score":0.02234596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2270468505831983,"score_gpt":0.5363378615330497,"score_spread":0.3092910109498514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}