{"id":"W3202259720","doi":"10.1172/jci152386","title":"Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Cilag; National Institute of Diabetes and Digestive and Kidney Diseases; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Grifols; Junta de Castilla y León; National Center for Advancing Translational Sciences; Consejo Superior de Investigaciones Científicas; Regione Toscana; Science for Life Laboratory; Fonds Léon Fredericq; Magnus Bergvalls Stiftelse; Norges Forskningsråd; NordForsk; Vetenskapsrådet; Technische Universität München; Ministero della Salute; Fonds Erasme; Fonds De La Recherche Scientifique - FNRS; King's College London; Jewish General Hospital; Public Health Agency of Canada; Bundesministerium für Bildung und Forschung; Helsingin Yliopisto; European Commission; Cancer Research UK; Deutsche Forschungsgemeinschaft; McGill University; Dipartimenti di Eccellenza; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Ministero dell’Istruzione, dell’Università e della Ricerca; ViiV Healthcare; Humanitas University; Public Health Agency; Japan Society for the Promotion of Science; GlaxoSmithKline; Biogen; Instituto de Salud Carlos III; Waalse Gewest; Università degli Studi di Siena; Associazione Italiana per la Ricerca sul Cancro; Eli Lilly and Company","keywords":"Odds ratio; Risk factor; Respiratory failure; Allele; Case-control study; Odds; Risk of mortality; Genetic predisposition; Respiratory system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.003569849,0.0001353199,0.0008251618,0.00005326516,0.0001197759,0.00002365126,0.0001527717,0.0001674429,0.00005546443],"category_scores_gemma":[0.2231329,0.00007846863,0.0007401877,0.0001724937,0.0006148183,0.00006464228,0.0001299535,0.000855826,0.000001130246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851114,"about_ca_system_score_gemma":0.002058825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001743585,"about_ca_topic_score_gemma":0.0001310684,"domain_scores_codex":[0.9961624,0.0008889448,0.001773825,0.0002301415,0.0007679846,0.0001767626],"domain_scores_gemma":[0.9814706,0.01540763,0.001385147,0.0003946123,0.0006268938,0.0007150504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006895954,0.0002917197,0.9902263,0.0003168726,0.0005347062,0.0000463106,0.0001519628,0.0002783973,0.000811769,0.00002395627,0.0005652487,0.006063202],"study_design_scores_gemma":[0.003017548,0.001629482,0.9823563,0.0001562752,0.0003901653,0.000009507831,0.00002723694,0.0007711435,0.0009073244,0.01031425,0.0003527185,0.00006810169],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905752,0.0001375829,0.0005868485,0.007865156,0.0002455697,0.0004248719,0.0001424102,0.000006307189,0.00001603071],"genre_scores_gemma":[0.9953974,0.0006455578,0.0008720313,0.002616625,0.0003639854,0.000004398096,0.000002873597,0.00001142919,0.00008573331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.219563,"threshold_uncertainty_score":0.783411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2270468505831983,"score_gpt":0.5363378615330497,"score_spread":0.3092910109498514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}