{"id":"W3202296806","doi":"10.2337/db21-0123","title":"Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Novo Nordisk Pharma; Kanae Foundation for the Promotion of Medical Science; Novo Nordisk; Ono Medical Research Foundation; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Japan IDDM network; Ministry of Education, Culture, Sports, Science and Technology; University of Alberta; Japan Foundation for Applied Enzymology; Takeda Science Foundation; Rotary Yoneyama Memorial Foundation; Suzuken Memorial Foundation; Institute for Molecular and Cellular Regulation, Gunma University; Japan Agency for Medical Research and Development","keywords":"Endoplasmic reticulum; Unfolded protein response; Cell biology; Thapsigargin; Apoptosis; CHOP; Downregulation and upregulation; Cell; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001144189,0.0004394869,0.0003647203,0.000246731,0.0001011508,0.000201732,0.0001805193,0.0001659316,0.0005430288],"category_scores_gemma":[0.00005580408,0.00006774092,0.0002182704,0.0001072173,0.0001373938,0.0002692172,0.0001213353,0.0006041975,0.0001110935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001509207,"about_ca_system_score_gemma":0.00009476631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008084843,"about_ca_topic_score_gemma":0.0001278672,"domain_scores_codex":[0.9999453,0.00001085691,0.000007761389,0.00001008767,0.000009314431,0.00001667437],"domain_scores_gemma":[0.9999738,0.00000269851,0.000008751023,0.000003549284,0.00000360808,0.000007732589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007507735,0.0002538847,0.0002887652,0.0001871877,0.00002133871,0.00008046888,0.00001517232,0.0001022859,0.9856849,0.0001035613,0.0001513957,0.01236026],"study_design_scores_gemma":[0.000113152,0.001550464,0.008283107,0.00001782682,0.00007517615,0.00034718,0.00002462803,0.0009007297,0.9833015,0.00007794466,0.005302841,0.000005454989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834625,0.01114729,0.002654594,0.0002297028,0.0001050278,0.00003370556,0.0001789602,0.0001864433,0.002001893],"genre_scores_gemma":[0.9908953,0.004952309,0.002232164,0.0001610004,0.00005193065,0.00004056214,0.0003199597,0.00002426709,0.001322576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005430288,"threshold_uncertainty_score":0.00181663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009670634170778835,"score_gpt":0.2130363807247006,"score_spread":0.2033657465539217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}