{"id":"W3202296806","doi":"10.2337/db21-0123","title":"Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway","year":2021,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Novo Nordisk Pharma; Kanae Foundation for the Promotion of Medical Science; Novo Nordisk; Ono Medical Research Foundation; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Japan IDDM network; Ministry of Education, Culture, Sports, Science and Technology; University of Alberta; Japan Foundation for Applied Enzymology; Takeda Science Foundation; Rotary Yoneyama Memorial Foundation; Suzuken Memorial Foundation; Institute for Molecular and Cellular Regulation, Gunma University; Japan Agency for Medical Research and Development","keywords":"Endoplasmic reticulum; Unfolded protein response; Cell biology; Thapsigargin; Apoptosis; CHOP; Downregulation and upregulation; Cell; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126615,0.0002308624,0.0003991818,0.00005959146,0.000193248,0.00008297319,0.00009728899,0.0001025962,0.000607909],"category_scores_gemma":[0.0006209996,0.0001626835,0.0001695167,0.0004643825,0.0001105335,0.00008148527,0.00006796719,0.0002210269,0.0002035992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003646165,"about_ca_system_score_gemma":0.0001023699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000120175,"about_ca_topic_score_gemma":3.963904e-7,"domain_scores_codex":[0.9984261,0.0001153355,0.0003137842,0.0003711309,0.0003079623,0.0004656531],"domain_scores_gemma":[0.9985218,0.0005321644,0.0001087302,0.0004899445,0.0001793835,0.0001680018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001012583,0.000200372,0.04208551,0.0001011011,0.0001081421,0.0000053883,0.000197536,0.000008327754,0.934544,0.0001318821,0.01659242,0.006015216],"study_design_scores_gemma":[0.0008619156,0.0001150121,0.001538483,0.00009436347,0.0001528089,0.00000254197,0.0007863594,0.001448552,0.9856958,0.0001374491,0.008976444,0.0001902734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821781,0.003667221,0.00001715119,0.001918323,0.0002630656,0.0002020813,0.00005827752,0.0001263333,0.01156948],"genre_scores_gemma":[0.9940603,0.0001553218,0.000579413,0.002247267,0.0001368312,0.0000664766,0.0001826224,0.00003882575,0.002532891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05115182,"threshold_uncertainty_score":0.6656177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009670634170778835,"score_gpt":0.2130363807247006,"score_spread":0.2033657465539217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}