{"id":"W3202312627","doi":"10.1002/cmdc.202100544","title":"Synthesis, Binding Affinity Analysis, and <sup>18</sup>F Radiosynthesis of Small‐Molecular‐Weight HIF‐1α‐Binding Compounds","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Cancer Foundation","keywords":"Microscale thermophoresis; Radiosynthesis; Chemistry; Small molecule; In vivo; Peptide; Stereochemistry; Molecule; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001366856,0.000403164,0.0002538965,0.0002272872,0.0001938675,0.0001454289,0.0002176502,0.0001890295,0.001979359],"category_scores_gemma":[0.0001892883,0.0001285415,0.0001999727,0.0002145876,0.0001791128,0.0001195883,0.00007730421,0.0003011539,0.0006187624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004221403,"about_ca_system_score_gemma":0.0003778547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001417017,"about_ca_topic_score_gemma":0.001538198,"domain_scores_codex":[0.9999264,0.00001535011,0.000003631437,0.0000130968,0.00001631205,0.00002516216],"domain_scores_gemma":[0.999892,0.00003406993,0.00002040838,0.000007207113,0.00002378682,0.00002252168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002349561,0.00007358039,0.000103999,0.0000723866,0.000007925385,0.00005828459,0.00002147533,0.001083975,0.9930055,0.0001674375,0.0001815413,0.004988974],"study_design_scores_gemma":[0.00005891729,0.0008744329,0.0008831013,0.000003781096,0.00001348965,0.0001026157,0.000009719558,0.0006587681,0.9945239,0.00003326247,0.002829639,0.000008336921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744577,0.003004078,0.01601634,0.0001404508,0.00003915768,0.0003643475,0.00137173,0.0001525427,0.004453591],"genre_scores_gemma":[0.97654,0.002050551,0.01503201,0.000114491,0.00002269409,0.0002787985,0.001994676,0.00005018629,0.003916531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979359,"threshold_uncertainty_score":0.006621599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01542841326357394,"score_gpt":0.2363917464196754,"score_spread":0.2209633331561014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}