{"id":"W3202320335","doi":"10.1146/annurev-pharmtox-052120-020445","title":"Repurposing Colchicine for Heart Disease","year":2021,"lang":"en","type":"article","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Colchicine; Medicine; Familial Mediterranean fever; Gout; Pericarditis; Internal medicine; Atrial fibrillation; Disease; Coronary artery disease; Cardiology; Repurposing; Aspirin; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765443,0.0001025172,0.0002465836,0.00001429589,0.0001110758,0.000002533851,0.0001114534,0.00006813825,0.00008674605],"category_scores_gemma":[0.0002340714,0.00007737435,0.0001020646,0.00006481595,0.0002117705,0.000003989407,0.0001175591,0.00007722847,0.000002426843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003153633,"about_ca_system_score_gemma":0.0001389282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.13319e-7,"about_ca_topic_score_gemma":0.00000210451,"domain_scores_codex":[0.9991128,0.0002120023,0.0002402388,0.0002088662,0.000038165,0.0001879181],"domain_scores_gemma":[0.9994189,0.00007457178,0.00008999468,0.0001678744,0.0002063928,0.00004227974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006220054,0.0001899705,0.0004638835,0.002345996,0.0002104115,0.000009771693,0.00007970526,0.000005982291,0.854205,0.001394626,0.1338066,0.006666074],"study_design_scores_gemma":[0.0009099256,0.0004363858,0.0008930302,0.0001562771,0.0002350141,0.00004977839,0.00009406122,0.00000646416,0.1318462,0.0002939125,0.8649599,0.0001190221],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2938248,0.6768679,0.0001749062,0.02669169,0.0005619755,0.0009542294,0.00009934897,0.00000861187,0.000816579],"genre_scores_gemma":[0.6841025,0.2236249,0.0002984565,0.08932555,0.000427328,0.0002885415,0.0002642912,0.00002803284,0.00164036],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7311533,"threshold_uncertainty_score":0.3155234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009032826707314418,"score_gpt":0.3227612623866922,"score_spread":0.3137284356793777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}