{"id":"W3202383747","doi":"10.1016/j.euroneuro.2021.08.200","title":"TH26. INVESTIGATING SEX DIFFERENCES IN THE POLYGENIC RISK OF MAJOR DEPRESSIVE DISORDER IN THE CANADIAN LONGITUDINAL STUDY ON AGING","year":2021,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Adrenocorticotropic hormone; Internal medicine; Dexamethasone suppression test; Endocrinology; Citalopram; Psychology; Major depressive disorder; Corticotropin-releasing hormone; Alcohol dependence; Major depressive episode; Hypothalamic–pituitary–adrenal axis; Hydrocortisone; Placebo; Stressor; Testosterone (patch); Medicine; Anxiety; Hormone; Antidepressant; Dexamethasone; Clinical psychology; Psychiatry; Alcohol; Biology; Amygdala","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001330229,0.0004986378,0.0002598332,0.0007536644,0.003382188,0.000659587,0.0009027618,0.0006150892,0.005048774],"category_scores_gemma":[0.00248066,0.0002747094,0.0006712133,0.001477528,0.0003045041,0.0002658777,0.0005160541,0.0005715434,0.000655145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004929387,"about_ca_system_score_gemma":0.01320701,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9668829,"about_ca_topic_score_gemma":0.9777995,"domain_scores_codex":[0.9994969,0.0000803282,0.00002426758,0.00008281995,0.0001207918,0.0001947562],"domain_scores_gemma":[0.998378,0.0001021611,0.0001739431,0.00009267856,0.000786089,0.0004670509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008679148,0.0001174617,0.9732486,0.00004342254,0.0001778318,0.0001942262,0.000739782,0.0002032727,0.001622011,0.0004044405,0.007241613,0.0151394],"study_design_scores_gemma":[0.00002479329,0.00005219738,0.9974942,0.000008806947,0.00004279095,0.00002922779,0.0001722672,0.00006655327,0.0001484444,0.00003573245,0.001919737,0.000005192859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550657,0.001160508,0.0005704815,0.00220922,0.0001707729,0.0002235727,0.02778332,0.00003642652,0.01278005],"genre_scores_gemma":[0.9617352,0.0006810529,0.001377795,0.000627763,0.00006514602,0.0002002974,0.01053258,0.0000373266,0.02474287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03311712,"threshold_uncertainty_score":0.06662422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06534190122120304,"score_gpt":0.3355928364104369,"score_spread":0.2702509351892339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}