{"id":"W3202418781","doi":"10.1139/cjc-2021-0121","title":"New pyrido[3′,2′:4,5]thieno[3,2-<i>d</i>]pyrimidin-4(3<i>H</i>)-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hybrid; Chemistry; Linezolid; Celecoxib; Minimum inhibitory concentration; Stereochemistry; In vitro; Staphylococcus aureus; Bacteria; Vancomycin; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001067921,0.0003291502,0.0002614547,0.0001994956,0.000147026,0.0002020123,0.0003702403,0.000355552,0.001431318],"category_scores_gemma":[0.0001256814,0.0001902796,0.0002283081,0.0001874191,0.0001275468,0.000339197,0.0002027869,0.0005035935,0.0004330734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124307,"about_ca_system_score_gemma":0.0001330757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002112334,"about_ca_topic_score_gemma":0.0006734655,"domain_scores_codex":[0.9999359,0.000007596948,0.0000049983,0.00001756002,0.00001729325,0.0000167041],"domain_scores_gemma":[0.9999416,0.000007824285,0.00001992291,0.000005527245,0.00001113542,0.00001411242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246081,0.00007046936,0.0002206615,0.0004114338,0.00003263276,0.0003707485,0.00008766006,0.0006855928,0.9873179,0.0008630007,0.0001631426,0.009652112],"study_design_scores_gemma":[0.00005675305,0.001594539,0.002144522,0.0000300139,0.00007406526,0.0009612169,0.00005465919,0.001247808,0.9738762,0.0001775737,0.01974945,0.00003328991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544134,0.0124053,0.02277544,0.0001974643,0.0001370413,0.0001925957,0.0007048544,0.0002150495,0.008958939],"genre_scores_gemma":[0.9759511,0.004160752,0.0132744,0.00009596278,0.00002525544,0.0001326798,0.0004481204,0.00001966736,0.005892218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431318,"threshold_uncertainty_score":0.00478822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008928817200873372,"score_gpt":0.1941665181817512,"score_spread":0.1852377009808779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}