{"id":"W3202418781","doi":"10.1139/cjc-2021-0121","title":"New pyrido[3′,2′:4,5]thieno[3,2-<i>d</i>]pyrimidin-4(3<i>H</i>)-one hybrids linked to arene units: synthesis of potential MRSA, VRE, and COX-2 inhibitors","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Hybrid; Chemistry; Linezolid; Celecoxib; Minimum inhibitory concentration; Stereochemistry; In vitro; Staphylococcus aureus; Bacteria; Vancomycin; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001959233,0.0002418435,0.0004460237,0.00008660374,0.000110142,0.00007300892,0.0002741569,0.000209195,0.0001634201],"category_scores_gemma":[0.0006947026,0.000246171,0.0001608285,0.000255258,0.0001229128,0.00001700774,0.00006746315,0.0001970496,0.000001446647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003753313,"about_ca_system_score_gemma":0.002379885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006548973,"about_ca_topic_score_gemma":0.0007401521,"domain_scores_codex":[0.9985657,0.00003948279,0.0005297504,0.0002828051,0.00021456,0.0003676997],"domain_scores_gemma":[0.9979035,0.00004310663,0.0002903271,0.0003056014,0.0005447205,0.0009127198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006342555,0.0000327116,0.000567887,0.0001084467,0.0001483095,0.00008742257,0.00009460739,0.0000612566,0.982503,0.00001014436,0.009796189,0.00652661],"study_design_scores_gemma":[0.0003972435,0.00007216357,0.000716219,0.0002629901,0.00009458338,0.0002451634,0.0005583167,0.000003909171,0.9660518,0.00008858931,0.03123159,0.0002774606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927354,0.004000354,0.0002930119,0.001233505,0.0002878706,0.00005162086,0.0001250981,0.000003414201,0.001269701],"genre_scores_gemma":[0.9961782,0.0003754748,0.0008061348,0.0003075328,0.001181517,0.000002143198,0.00002440893,0.00003541609,0.001089203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0214354,"threshold_uncertainty_score":0.999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008928817200873372,"score_gpt":0.1941665181817512,"score_spread":0.1852377009808779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}