{"id":"W3202429170","doi":"10.3389/fcell.2021.703670","title":"Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Tufts Medical Center; American Heart Association; York University; New Jersey Health Foundation; Musculoskeletal Transplant Foundation; National Institutes of Health; National Science Foundation","keywords":"Osteoarthritis; Cartilage; Myokine; Inflammation; Knockout mouse; Chondrogenesis; Endocrinology; Internal medicine; Pathogenesis; Medicine; Pathology; Skeletal muscle; Receptor; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002908436,0.0003271287,0.0003826859,0.000382189,0.0001958883,0.0002791566,0.0001572835,0.0002467235,0.0007685547],"category_scores_gemma":[0.0001313814,0.0001245626,0.0003322762,0.0001795249,0.0004130815,0.0003100546,0.0002260414,0.0005292759,0.000138079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090965,"about_ca_system_score_gemma":0.0002255619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002532037,"about_ca_topic_score_gemma":0.0004457722,"domain_scores_codex":[0.9998639,0.00003592044,0.00001803439,0.00002353721,0.00002553333,0.00003309619],"domain_scores_gemma":[0.9998405,0.00001816238,0.00006957349,0.00001266795,0.00001483813,0.00004427659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007548691,0.000083599,0.001178231,0.0002673834,0.00001956292,0.0002262401,0.00003297714,0.0001422455,0.9906756,0.000365035,0.00006037827,0.006193866],"study_design_scores_gemma":[0.000139889,0.002188058,0.0628774,0.00005875218,0.0001845006,0.001102682,0.0001998555,0.001395611,0.9241643,0.0005014041,0.007155526,0.00003195227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543986,0.0339361,0.007238943,0.0004468542,0.0000797562,0.00008495268,0.0003579207,0.0001342586,0.003322613],"genre_scores_gemma":[0.9842799,0.00994275,0.003597138,0.000107179,0.00003597378,0.00005031602,0.0001525398,0.00001179474,0.001822298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007685547,"threshold_uncertainty_score":0.002571046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009195223568730688,"score_gpt":0.2351918932441465,"score_spread":0.2259966696754159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}