{"id":"W3202444680","doi":"10.1038/s41419-021-04202-9","title":"p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress","year":2021,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Childhood Cancer Survivors' Quality of Life","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; McGill University","funders":"National Center for Advancing Translational Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Compute Canada; Canada Research Chairs; Government of Canada; McGill University","keywords":"Haematopoiesis; Progenitor cell; Bone marrow; Stem cell; Biology; Cancer research; DNA damage; Immunology; Hematopoietic stem cell; Cell biology; Bone marrow failure; Context (archaeology); Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150421,0.0003471846,0.0002634515,0.0002691287,0.0001947875,0.0003318432,0.0001592392,0.0003251177,0.002036603],"category_scores_gemma":[0.0001077643,0.0001348955,0.0002961149,0.0001501857,0.0003068381,0.0002228908,0.0002884483,0.000508228,0.0004903623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001884487,"about_ca_system_score_gemma":0.0001949824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000425711,"about_ca_topic_score_gemma":0.0007915454,"domain_scores_codex":[0.9998463,0.00001432595,0.000008703676,0.00005033045,0.00004749045,0.00003278696],"domain_scores_gemma":[0.9999139,0.00001209807,0.00002591046,0.00001054931,0.00001807785,0.00001940844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008339183,0.00001166773,0.0007656045,0.00004552635,0.000006806726,0.0000476796,0.0000167167,0.00006479702,0.9977329,0.00005585341,0.00005277193,0.001116352],"study_design_scores_gemma":[0.000009563902,0.0002029692,0.05100597,0.00001388138,0.00002971875,0.00022478,0.0001009837,0.0007936645,0.9450675,0.0001126075,0.002432126,0.000006114019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879809,0.003302292,0.005682309,0.0001526649,0.00003860304,0.00003449883,0.001168329,0.0001797894,0.001460629],"genre_scores_gemma":[0.9915882,0.001444529,0.001430121,0.00008645189,0.00001345685,0.00005851932,0.001358581,0.0000350552,0.003985139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036603,"threshold_uncertainty_score":0.006813109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01969186819710175,"score_gpt":0.2704005937071599,"score_spread":0.2507087255100581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}