{"id":"W3202459294","doi":"10.1038/s41467-021-26163-5","title":"Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; National Institutes of Health; Feldstein Medical Foundation; Michael Smith Health Research BC; Stony Brook University; State University of New York; Burroughs Wellcome Fund; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Veterans Affairs","keywords":"Cryptococcus neoformans; Ergosterol; Phenocopy; Yeast; Microbiology; Cryptococcus; Biology; Glycolipid; In vitro; Mutant; Enzyme; Growth inhibition; Antifungal; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001108898,0.0004059004,0.0001449426,0.0002508316,0.0001172985,0.0002169965,0.0003324993,0.0002804261,0.0006738208],"category_scores_gemma":[0.00004385553,0.000134281,0.0002373081,0.0001515284,0.0001716959,0.0001162676,0.0001139824,0.000510417,0.0003393348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004880292,"about_ca_system_score_gemma":0.0003273389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412032,"about_ca_topic_score_gemma":0.002067436,"domain_scores_codex":[0.9999498,0.000006326485,0.000003243723,0.000006792851,0.00002012356,0.00001370465],"domain_scores_gemma":[0.9999793,0.000001935093,0.000005964224,0.000002250277,0.000004327589,0.000006310883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001351497,0.0001128159,0.0001370243,0.00008504884,0.000007950837,0.0001209773,0.00001233674,0.001000278,0.9911408,0.0007859346,0.000193579,0.006268071],"study_design_scores_gemma":[0.0000953845,0.0007223505,0.000940915,0.00001622021,0.00001551002,0.0003339772,0.00001139911,0.001961599,0.9833074,0.0001718984,0.01241704,0.000006335175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9496199,0.01960432,0.01120558,0.001244661,0.0001693478,0.0002620779,0.001067358,0.0001715575,0.0166552],"genre_scores_gemma":[0.9787135,0.007893257,0.00676877,0.0002656116,0.00001750868,0.00005265401,0.0006950665,0.00001183535,0.0055818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001412032,"threshold_uncertainty_score":0.003540933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610066804987264,"score_gpt":0.3245859444281833,"score_spread":0.2984852763783106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}