{"id":"W3202459294","doi":"10.1038/s41467-021-26163-5","title":"Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Health and Human Services; National Institutes of Health; Feldstein Medical Foundation; Michael Smith Health Research BC; Stony Brook University; State University of New York; Burroughs Wellcome Fund; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; U.S. Department of Veterans Affairs","keywords":"Cryptococcus neoformans; Ergosterol; Phenocopy; Yeast; Microbiology; Cryptococcus; Biology; Glycolipid; In vitro; Mutant; Enzyme; Growth inhibition; Antifungal; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006659312,0.00008668147,0.0001732147,0.00009336695,0.0002203196,0.00001530402,0.00007549532,0.0001351496,0.00004975867],"category_scores_gemma":[0.0004066295,0.00007681092,0.00003062896,0.0006117627,0.00007136964,0.00006241941,0.000296609,0.000433806,0.000004646438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003210341,"about_ca_system_score_gemma":0.0000965935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009582294,"about_ca_topic_score_gemma":0.0002819477,"domain_scores_codex":[0.9994349,0.00004495616,0.0001905447,0.000120243,0.0001063544,0.0001029574],"domain_scores_gemma":[0.9984436,0.000101285,0.00004758229,0.0006588587,0.0006780284,0.00007065711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001532765,0.001050352,0.3411376,0.0004622469,0.0006307206,0.00004191136,0.005154712,0.00002622947,0.5455968,0.02969884,0.05546008,0.02058722],"study_design_scores_gemma":[0.0008862572,0.0001320636,0.8283125,0.0002668363,0.0001401395,0.00008010232,0.0005761946,0.0001176678,0.08627644,0.0002094301,0.08281903,0.0001833021],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875537,0.003859997,0.0001260048,0.005101495,0.0001197077,0.0002995591,0.0001079833,0.00003186163,0.002799672],"genre_scores_gemma":[0.9885327,0.0006268843,0.009491658,0.0009433074,0.00002571036,0.00001768828,0.0001730173,0.000008478352,0.0001805447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4871749,"threshold_uncertainty_score":0.3132259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610066804987264,"score_gpt":0.3245859444281833,"score_spread":0.2984852763783106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}