{"id":"W3202501045","doi":"10.4269/ajtmh.20-1578","title":"Results of a Double-Blind, Randomized, Placebo-Controlled Phase 1 Study to Evaluate the Safety and Pharmacokinetics of Anti-Zika Virus Immunoglobulin","year":2021,"lang":"en","type":"article","venue":"American Journal of Tropical Medicine and Hygiene","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Zika virus; Medicine; Placebo; Adverse effect; Microcephaly; Pharmacokinetics; Population; Pregnancy; Internal medicine; Pediatrics; Virology; Virus; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004065619,0.001670773,0.00357768,0.0004702054,0.0007625296,0.0006856041,0.0009895392,0.002261014,0.006817068],"category_scores_gemma":[0.003611276,0.0008878934,0.001102943,0.0003332835,0.001385099,0.001138587,0.0002614041,0.002498075,0.0009695334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00042081,"about_ca_system_score_gemma":0.00169231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004094664,"about_ca_topic_score_gemma":0.0009576438,"domain_scores_codex":[0.9985661,0.0007636636,0.0001460872,0.0002328023,0.0001396749,0.0001517214],"domain_scores_gemma":[0.9978248,0.0008055396,0.0003954249,0.000155767,0.0002879467,0.0005305123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9411933,0.03289674,0.0007034416,0.00101401,0.0006021553,0.00005420892,0.00006624591,0.0002400095,0.006339603,0.000100603,0.001058847,0.01573087],"study_design_scores_gemma":[0.8609087,0.135109,0.002005971,0.00003269885,0.0002997337,0.00002364901,0.00001090468,0.0002004773,0.000689306,0.00008047902,0.0006276353,0.00001128104],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506438,0.006446704,0.002841595,0.0009304805,0.001148263,0.03086678,0.002518664,0.0003461905,0.004257474],"genre_scores_gemma":[0.9545246,0.00506643,0.006321525,0.002515313,0.0008482421,0.02397059,0.002226479,0.00006918063,0.004457557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006817068,"threshold_uncertainty_score":0.02280539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473169078773816,"score_gpt":0.3582437012267427,"score_spread":0.3335120104390045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}