{"id":"W3202515317","doi":"10.1101/2021.10.07.463317","title":"Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"H2020 Marie Skłodowska-Curie Actions; Horizon 2020 Framework Programme; Diabetes Fonds; ZonMw; European Commission; Canadian Institutes of Health Research; CH.I.L.D. Foundation; Amsterdam University Medical Centers","keywords":"Flagellin; TLR5; In vivo; Inflammation; Biology; Proinsulin; Beta cell; Pancreatic islets; Type 2 diabetes; Islet; Gut flora; Insulin; In vitro; Gene knockdown; Internal medicine; Endocrinology; Immunology; Cell biology; Receptor; Diabetes mellitus; Gene; Medicine; TLR2; Biochemistry; TLR4","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002892974,0.0005839178,0.0004168792,0.0005402113,0.0001776216,0.0005737041,0.000202831,0.0003978228,0.01659237],"category_scores_gemma":[0.0001833065,0.0001383766,0.0003594312,0.0005384809,0.0001729104,0.0002210888,0.0003710565,0.0007434956,0.002719809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002828217,"about_ca_system_score_gemma":0.0002928514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004840025,"about_ca_topic_score_gemma":0.0003835897,"domain_scores_codex":[0.9998343,0.00002571085,0.000006708776,0.00003535131,0.00005627088,0.00004170513],"domain_scores_gemma":[0.9999092,0.00001019945,0.0000275912,0.00001087189,0.00001489868,0.00002732963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003771128,0.0002654341,0.003948004,0.00186206,0.000220577,0.0006012649,0.00008320645,0.0009010256,0.9336188,0.001815742,0.01829632,0.03461641],"study_design_scores_gemma":[0.0006716168,0.001550638,0.06656979,0.000266882,0.0002320831,0.00120165,0.0003103453,0.006505254,0.8493552,0.003525328,0.06975862,0.00005260559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8963608,0.01628803,0.0209613,0.005817675,0.00315397,0.0002883747,0.03678602,0.001931175,0.0184128],"genre_scores_gemma":[0.9242682,0.01005124,0.006598961,0.0007635647,0.0004254669,0.0001249576,0.01757964,0.0002305046,0.03995721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01659237,"threshold_uncertainty_score":0.05550694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515205423187338,"score_gpt":0.2113356381650727,"score_spread":0.1961835839331993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}