{"id":"W3202540433","doi":"10.1101/2021.10.04.463079","title":"A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience of respiration and sleep","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Cardiovascular Research Institute of Vermont, Larner College of Medicine, University of Vermont; National Institute of General Medical Sciences; University of California, San Francisco","keywords":"Carotid body; Glomus cell; Chemoreceptor; Mitochondrion; Hypoxic ventilatory response; Peripheral chemoreceptors; Hypoxia (environmental); Protein subunit; Biology; Cell biology; Oxygen; Endocrinology; Chemistry; Internal medicine; Biochemistry; Receptor; Respiration; Anatomy; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009607144,0.0001761954,0.0001508528,0.0001337882,0.0001088321,0.0002122959,0.0001448063,0.0002023336,0.0007093397],"category_scores_gemma":[0.0001228176,0.0000709262,0.0001424423,0.00008545726,0.0001918181,0.00008557183,0.0001859123,0.0002929463,0.00016326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003488027,"about_ca_system_score_gemma":0.00008150378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003524376,"about_ca_topic_score_gemma":0.000343937,"domain_scores_codex":[0.999915,0.00001054383,0.000008853109,0.00002271409,0.00002234333,0.00002061132],"domain_scores_gemma":[0.9998771,0.00001703984,0.00004525676,0.00001444303,0.00001113328,0.00003497255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002292467,0.000003562684,0.0002742061,0.000005757593,0.000001507967,0.00002933027,0.000002275339,0.00001312548,0.9994453,0.00003143826,0.000008595995,0.0001620019],"study_design_scores_gemma":[0.00001829223,0.0002299057,0.03509592,0.000006537053,0.00002565435,0.001186582,0.00003557076,0.002318436,0.9590982,0.0000677571,0.001910062,0.000007147515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978516,0.0004760841,0.001114696,0.0000410027,0.00001597243,0.000007454382,0.000101919,0.0000249086,0.0003664211],"genre_scores_gemma":[0.9983749,0.0002063811,0.0006138549,0.00003341819,0.000007332263,0.000007236549,0.0002530509,0.000005079297,0.0004987134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007093397,"threshold_uncertainty_score":0.002530754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674599644359521,"score_gpt":0.2264754535683264,"score_spread":0.2097294571247312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}