{"id":"W3202548457","doi":"10.3390/v13102002","title":"Macrophage Depletion via Clodronate Pretreatment Reduces Transgene Expression from AAV Vectors In Vivo","year":2021,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Transgene; White pulp; Genetic enhancement; In vivo; Gene delivery; Spleen; Transduction (biophysics); Viral vector; Biology; Immune system; Transfection; Adeno-associated virus; Molecular biology; Cancer research; Cell biology; Immunology; Vector (molecular biology); Gene; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003776,0.0004602298,0.0004843945,0.00029869,0.000160919,0.0004678941,0.0002738337,0.0003982736,0.001100136],"category_scores_gemma":[0.0002597049,0.0002475409,0.0002496411,0.0001055368,0.0003856113,0.0002785967,0.0002032234,0.0007086533,0.0004036807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145459,"about_ca_system_score_gemma":0.0004954769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001928698,"about_ca_topic_score_gemma":0.004071158,"domain_scores_codex":[0.9996966,0.00007289647,0.00002799594,0.00006558908,0.00006398166,0.00007290119],"domain_scores_gemma":[0.9997286,0.0000808806,0.00009005191,0.00002736796,0.00002609669,0.00004694399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000780213,0.00002007101,0.00004169828,0.00001435378,0.000002348475,0.00001027797,0.00001199183,0.00001908826,0.9994088,0.00003031997,0.00001367283,0.0003493422],"study_design_scores_gemma":[0.00001135605,0.0004117051,0.0008291279,0.000004707753,0.000009953045,0.00005664315,0.00001434763,0.0003180635,0.9976306,0.00001462487,0.0006963968,0.000002450264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885594,0.002393016,0.006837331,0.0001917065,0.00006075306,0.00009122542,0.0002750079,0.0002015532,0.001389851],"genre_scores_gemma":[0.9884498,0.001408253,0.005154754,0.00008212632,0.00002052952,0.00008786524,0.0003593941,0.0000704493,0.004366759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001928698,"threshold_uncertainty_score":0.003834903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02118776969689968,"score_gpt":0.2981721221687924,"score_spread":0.2769843524718927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}