{"id":"W3202625913","doi":"10.3389/fendo.2021.726368","title":"Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia","year":2021,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Hyperglucagonemia; Alpha cell; Glucagon; Proglucagon; Secretion; Paracrine signalling; Endocrinology; Diabetes mellitus; Internal medicine; Cell biology; Glucose homeostasis; Biology; Glucagon-like peptide-1; Beta cell; Medicine; Type 2 diabetes; Insulin; Insulin resistance; Receptor; Islet","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003241693,0.0006854861,0.001031157,0.001539222,0.0002072638,0.0009437392,0.0005941602,0.0007862714,0.003219794],"category_scores_gemma":[0.0003064846,0.0001915851,0.0003571846,0.001636039,0.0003300228,0.001232069,0.0006704636,0.00162473,0.002469265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004519883,"about_ca_system_score_gemma":0.0006594625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004237401,"about_ca_topic_score_gemma":0.0007214129,"domain_scores_codex":[0.9999056,0.00001473514,0.00001235745,0.00001513062,0.00003726818,0.00001482236],"domain_scores_gemma":[0.999894,0.00003703593,0.00001612421,0.000004186505,0.00002965,0.00001893536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001267994,0.00006735131,0.0001561783,0.01521122,0.00006890992,0.0004042673,0.0000734149,0.0003391323,0.007068482,0.006218713,0.03061419,0.9396513],"study_design_scores_gemma":[0.00001423728,0.00008242283,0.0006600214,0.001957268,0.00006043752,0.001381029,0.00005162332,0.00006757871,0.0007125465,0.002277608,0.9927208,0.00001443466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001699422,0.9978533,0.0001922098,0.0002680257,0.0002332555,0.000003595522,0.00002292573,0.00001164103,0.00124508],"genre_scores_gemma":[0.0005536866,0.9983588,0.0001780736,0.0001305529,0.000120559,0.000004188804,0.00003391251,0.000001547481,0.0006187108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003219794,"threshold_uncertainty_score":0.01077127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03949814410093191,"score_gpt":0.2780093160681071,"score_spread":0.2385111719671752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}