{"id":"W3202631322","doi":"10.1136/jitc-2021-003272","title":"Multicenter, double-blind, placebo-controlled trial of seviprotimut-L polyvalent melanoma vaccine in patients with post-resection melanoma at high risk of recurrence","year":2021,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Princess Margaret Cancer Centre; Université Laval","funders":"National Cancer Institute; Ministry of Science and ICT, South Korea; UVA Cancer Center; University of Virginia","keywords":"Medicine; Clinical endpoint; Melanoma; Placebo; Internal medicine; Adverse effect; Adjuvant; Randomized controlled trial; Gastroenterology; Phases of clinical research; Clinical trial; Oncology; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008363895,0.000321508,0.001231148,0.0003645127,0.0001854326,0.00001343071,0.000322929,0.0002698635,0.0008913654],"category_scores_gemma":[0.0001228715,0.0002370073,0.0004820882,0.0002733021,0.0001351469,0.0002059922,0.00004055322,0.0004341973,0.000002463853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979,"about_ca_system_score_gemma":0.0003906778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005957264,"about_ca_topic_score_gemma":0.0002702569,"domain_scores_codex":[0.9970039,0.0006389326,0.001494152,0.0002787075,0.0001870679,0.0003972444],"domain_scores_gemma":[0.9959936,0.0004869907,0.002051966,0.0004051629,0.001039788,0.00002249473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7922434,0.001449267,0.02637213,0.00006566886,0.002639507,0.000001136643,0.000577991,0.00006093876,0.1630821,0.00001280613,0.00004070083,0.01345439],"study_design_scores_gemma":[0.6296409,0.007542115,0.03751237,0.0003627581,0.0001778643,0.00001242052,0.00009576639,0.000002881723,0.3228123,0.00001307989,0.001641848,0.0001856923],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611537,0.03349479,0.00005723892,0.0001345863,0.002300981,0.002658051,0.0001744184,0.000007539008,0.00001868791],"genre_scores_gemma":[0.9888156,0.009351173,0.0001388479,0.00003352335,0.00005141558,0.0002615112,0.00006105923,0.00004475313,0.001242092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1626024,"threshold_uncertainty_score":0.9759826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130773580450612,"score_gpt":0.2810383951323538,"score_spread":0.2697306593278477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}