{"id":"W3202652452","doi":"10.1111/bph.15689","title":"<i>In vitro</i> and <i>in vivo</i> anti‐epileptic efficacy of eslicarbazepine acetate in a mouse model of <i>KCNQ2</i>‐related self‐limited epilepsy","year":2021,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Berlin Institute of Health; NeuroCure Exzellenzcluster; Fundação Bial; Eisai; Kempe Foundation","keywords":"In vivo; Pharmacology; Epilepsy; Hippocampal formation; Medicine; Internal medicine; Neuroscience; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002595596,0.0008722453,0.0005281936,0.0003135931,0.0001161278,0.0002546604,0.0003804437,0.0004689984,0.001158042],"category_scores_gemma":[0.0001380904,0.0002655484,0.0004250681,0.0001589621,0.000371524,0.0004349146,0.0001102806,0.0009407498,0.0003956561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003004238,"about_ca_system_score_gemma":0.0002324853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006574381,"about_ca_topic_score_gemma":0.001069173,"domain_scores_codex":[0.9997472,0.00005356187,0.00004051596,0.00004959889,0.00004619449,0.00006285046],"domain_scores_gemma":[0.9997559,0.00002715658,0.0001024767,0.00002297792,0.00003335586,0.00005808694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006158563,0.0001123493,0.00008512993,0.00006123737,0.0000119623,0.00004374372,0.00001088858,0.00006752093,0.9983338,0.00002684187,0.00007116034,0.0005595054],"study_design_scores_gemma":[0.0001375465,0.00330523,0.002600678,0.000008583736,0.00005770957,0.0001727131,0.00002604453,0.000500033,0.9925033,0.00002183099,0.0006579235,0.000008313986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933537,0.001582385,0.001625574,0.0002197301,0.00009240337,0.00007250908,0.001012649,0.0002518769,0.001789199],"genre_scores_gemma":[0.99063,0.001692251,0.002634436,0.0001509795,0.00005122321,0.0001972232,0.00137096,0.00006176483,0.003211113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158042,"threshold_uncertainty_score":0.003874004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008644993030678668,"score_gpt":0.2503136484589608,"score_spread":0.2416686554282821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}