{"id":"W3202684981","doi":"10.3389/frph.2021.726936","title":"Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Reproductive Health","topic":"Endometriosis Research and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Cannabinoid receptor; Angiogenesis; Protein kinase B; Cannabinoid; Inflammation; Cancer research; MAPK/ERK pathway; Agonist; Pharmacology; Medicine; Endocannabinoid system; Apoptosis; Signal transduction; Immunology; Biology; Internal medicine; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001390984,0.0003235173,0.001171409,0.002258737,0.000169112,0.00003133431,0.00008570039,0.0001072505,0.00001220515],"category_scores_gemma":[0.003926074,0.0003068053,0.0001094805,0.002616122,0.0002154457,0.0001389419,0.0001129173,0.0003097917,5.015002e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000577771,"about_ca_system_score_gemma":0.0006301768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008917804,"about_ca_topic_score_gemma":0.000122894,"domain_scores_codex":[0.9963655,0.0003852887,0.0008860085,0.001178304,0.0005317447,0.0006531175],"domain_scores_gemma":[0.9980792,0.0003121109,0.0002625383,0.0005957783,0.0003926114,0.0003577249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001332689,0.005077682,0.7698043,0.005070657,0.0005277595,0.0001515125,0.003527616,0.001292193,0.1896367,0.00008363197,0.001420022,0.0220752],"study_design_scores_gemma":[0.008488302,0.001663177,0.01932789,0.0004633431,0.0001314328,0.00007100963,0.001110581,0.00212245,0.9654257,0.0005632906,0.0002417779,0.000391028],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9308945,0.06170231,0.002333556,0.002829906,0.0001318929,0.001941288,0.00006755711,0.00002583986,0.00007315724],"genre_scores_gemma":[0.9668463,0.006358827,0.02595197,0.000111783,0.00009384361,0.0002004372,0.00008756425,0.00004561909,0.0003036924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.775789,"threshold_uncertainty_score":0.9999384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139528049531783,"score_gpt":0.2922966778131322,"score_spread":0.2709013973178144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}