{"id":"W3202684981","doi":"10.3389/frph.2021.726936","title":"Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Reproductive Health","topic":"Endometriosis Research and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Cannabinoid receptor; Angiogenesis; Protein kinase B; Cannabinoid; Inflammation; Cancer research; MAPK/ERK pathway; Agonist; Pharmacology; Medicine; Endocannabinoid system; Apoptosis; Signal transduction; Immunology; Biology; Internal medicine; Receptor; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002524543,0.0003232053,0.0002558439,0.0004389734,0.0002989447,0.0003623225,0.0002211518,0.0003215227,0.001375965],"category_scores_gemma":[0.0001345901,0.0002073407,0.0004002555,0.0003260597,0.0002456384,0.0002433867,0.0001555921,0.001001781,0.0003078138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097963,"about_ca_system_score_gemma":0.0004762175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001717506,"about_ca_topic_score_gemma":0.003502789,"domain_scores_codex":[0.9997371,0.0000442803,0.00003656737,0.00003870485,0.0000797668,0.00006356556],"domain_scores_gemma":[0.9999404,0.000008482752,0.00001558132,0.00001079359,0.00001062335,0.00001415888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008242971,0.0003831931,0.0005115586,0.0001787127,0.00002160686,0.0001514505,0.00005555702,0.0002840568,0.9921299,0.0004221095,0.0002724855,0.004764944],"study_design_scores_gemma":[0.0001176115,0.001194632,0.004345261,0.00002041496,0.00005682158,0.0004471883,0.0001005475,0.00136059,0.9876971,0.0001441425,0.004505957,0.000009703233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841247,0.005521268,0.004591689,0.0004162656,0.0001387129,0.0001069898,0.001039021,0.00008879266,0.003972569],"genre_scores_gemma":[0.985297,0.004581429,0.004856343,0.0001366063,0.00002067355,0.0001334597,0.0007835304,0.00001353378,0.004177362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001717506,"threshold_uncertainty_score":0.004603088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02139528049531783,"score_gpt":0.2922966778131322,"score_spread":0.2709013973178144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}