{"id":"W3202695285","doi":"10.1016/j.isci.2021.103225","title":"IL-17A reprograms intestinal epithelial cells to facilitate HIV-1 replication and outgrowth in CD4+ T cells","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; McGill University Health Centre; Caprion (Canada); Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Office of Extramural Research, National Institutes of Health; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; National Institute on Aging; Université de Montréal; Canada Foundation for Innovation; Fondation du CHUM","keywords":"Interleukin 17; Chemokine; Crosstalk; Immunology; CCL20; Viral load; Viral replication; Cytokine; Biology; Interferon; Human immunodeficiency virus (HIV); Virology; Medicine; Inflammation; Virus; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491976,0.0001583061,0.0002004237,0.0001294954,0.0001660239,0.0005547079,0.0001140819,0.0002106737,0.00364616],"category_scores_gemma":[0.0001583445,0.0001210023,0.000221746,0.00008447414,0.000206527,0.0001658212,0.0002352194,0.0008258187,0.0007850781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001676106,"about_ca_system_score_gemma":0.0002093632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005905317,"about_ca_topic_score_gemma":0.000940809,"domain_scores_codex":[0.9998149,0.00004595655,0.00001257092,0.00003207116,0.00004389992,0.00005072447],"domain_scores_gemma":[0.999926,0.00002030843,0.000009987511,0.00001472586,0.000009753416,0.00001923121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002415687,0.00003895273,0.00086947,0.00006384961,0.000007377825,0.000127237,0.00007174184,0.0001084389,0.9933715,0.00007845125,0.000160039,0.004861394],"study_design_scores_gemma":[0.00003305363,0.0005386463,0.01339325,0.00002884697,0.00002366049,0.0004529062,0.0002999383,0.001197839,0.9756181,0.0001543097,0.008252465,0.00000706498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937549,0.001399489,0.001524881,0.0001856886,0.00006056571,0.00002309543,0.0006419767,0.00007490016,0.002334627],"genre_scores_gemma":[0.9929387,0.0005609693,0.001780894,0.0001246411,0.0000182546,0.00003877205,0.0005719361,0.0000448756,0.003921063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00364616,"threshold_uncertainty_score":0.01219761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03467315118878141,"score_gpt":0.2802629611920057,"score_spread":0.2455898100032243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}