{"id":"W3202714042","doi":"10.1158/1078-0432.ccr-19-2384","title":"HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA","year":2021,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"University of Toronto; Princess Margaret Cancer Foundation; Cancer Research Society; Conquer Cancer Foundation","keywords":"Digital polymerase chain reaction; Genotyping; Oncology; Medicine; Internal medicine; Cancer; Cervical cancer; DNA sequencing; Liquid biopsy; DNA; Genotype; Polymerase chain reaction; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001696419,0.0002752038,0.0005955276,0.0001202246,0.0001529665,0.00006096263,0.0003333906,0.0008589451,0.0002135023],"category_scores_gemma":[0.004322829,0.0002890633,0.0004188825,0.0002771209,0.0005930671,0.000004431523,0.0003433682,0.00226157,0.00001339955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002644456,"about_ca_system_score_gemma":0.001929315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001204395,"about_ca_topic_score_gemma":0.0005074023,"domain_scores_codex":[0.9960873,0.0007357814,0.0008716594,0.001020765,0.0006139384,0.0006706275],"domain_scores_gemma":[0.9962235,0.00135448,0.0002803723,0.0007313556,0.001272032,0.0001382436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003227427,0.00009546828,0.001155692,0.001023502,0.0006391361,0.0008524441,0.0001739262,0.0002343479,0.6932977,0.000008345174,0.2495222,0.05267441],"study_design_scores_gemma":[0.0009704518,0.0009662799,0.002152765,0.0002409723,0.0001004617,0.0000468877,0.0004790622,0.0001426672,0.5310866,0.0001958961,0.4629254,0.0006925688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9436514,0.01097576,0.0004039271,0.03670511,0.002119708,0.001081075,0.001715838,0.00002638967,0.003320791],"genre_scores_gemma":[0.9333721,0.005082596,0.000155939,0.04905259,0.01028517,0.000157795,0.0009360819,0.000115983,0.0008416925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2134032,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1503817589627792,"score_gpt":0.4312074346837192,"score_spread":0.28082567572094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}