{"id":"W3202714042","doi":"10.1158/1078-0432.ccr-19-2384","title":"HPV Sequencing Facilitates Ultrasensitive Detection of HPV Circulating Tumor DNA","year":2021,"lang":"en","type":"letter","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"University of Toronto; Princess Margaret Cancer Foundation; Cancer Research Society; Conquer Cancer Foundation","keywords":"Digital polymerase chain reaction; Genotyping; Oncology; Medicine; Internal medicine; Cancer; Cervical cancer; DNA sequencing; Liquid biopsy; DNA; Genotype; Polymerase chain reaction; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00106339,0.000443049,0.0003380189,0.0003916947,0.0001505711,0.0005395596,0.0003505585,0.0004933014,0.002330289],"category_scores_gemma":[0.001983988,0.0002893842,0.0002904642,0.0002093303,0.000319294,0.0004412958,0.0003919624,0.0005938638,0.0005080546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003161133,"about_ca_system_score_gemma":0.0004435054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004849117,"about_ca_topic_score_gemma":0.0009477671,"domain_scores_codex":[0.9992,0.0002703728,0.00003944432,0.0002263569,0.0002024377,0.00006136583],"domain_scores_gemma":[0.9989684,0.0004628694,0.0002250267,0.0001074873,0.0001791317,0.00005706232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009332713,0.0002444879,0.02206171,0.0003637035,0.00005651507,0.00004920431,0.0000765907,0.001201391,0.9380172,0.000253752,0.0004589875,0.03628322],"study_design_scores_gemma":[0.00009967742,0.002393109,0.0338292,0.00005986012,0.0001444777,0.0007483761,0.00006574918,0.01522638,0.9410201,0.0005315868,0.005853843,0.00002757306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902662,0.004698845,0.08638212,0.0004540291,0.0001509787,0.0003112552,0.0024893,0.0006173883,0.002233961],"genre_scores_gemma":[0.9510794,0.00142341,0.04339257,0.0003567634,0.00006861416,0.000220115,0.001772063,0.00007783208,0.001609237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002330289,"threshold_uncertainty_score":0.007795632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1503817589627792,"score_gpt":0.4312074346837192,"score_spread":0.28082567572094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}