{"id":"W3202756693","doi":"10.1177/1934578x211045465","title":"Resveratrol and Quercetin Potentiate the Cell Protection and Rescue Effects of NAD <sup>+</sup> Precursors in HEK293 Cells Challenged by DNA Damaging Agent, <i>N</i> -Methyl- <i>N′</i> -nitro- <i>N</i> -nitrosoguanidine","year":2021,"lang":"en","type":"article","venue":"Natural Product Communications","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"NAD+ kinase; Resveratrol; DNA damage; HEK 293 cells; Nicotinamide adenine dinucleotide; Chemistry; PARP1; Biochemistry; Nicotinamide; DNA repair; Molecular biology; DNA; Biology; Poly ADP ribose polymerase; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042826,0.00033199,0.0005952569,0.0001704791,0.0004220915,0.00005348396,0.0003975798,0.000153308,0.000007351552],"category_scores_gemma":[0.0005927633,0.0002425185,0.0001045001,0.0007091967,0.0005345851,0.0001729829,0.000445167,0.001625499,0.000002962892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007636024,"about_ca_system_score_gemma":0.0001290049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00044585,"about_ca_topic_score_gemma":0.0001372465,"domain_scores_codex":[0.9969889,0.0009764833,0.0006286098,0.0005901618,0.0004160593,0.0003998034],"domain_scores_gemma":[0.997049,0.0004054117,0.0001846077,0.00186128,0.0003540997,0.0001455873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002061421,0.0004747714,0.0005182756,0.0007680125,0.0001078606,0.00002206997,0.001991032,0.00005577535,0.9883268,0.00006203653,0.002683877,0.004783373],"study_design_scores_gemma":[0.007650002,0.0005941257,0.004759499,0.00132574,0.0006301703,0.0003329371,0.002486741,0.009247991,0.9497626,0.0001831573,0.02245559,0.0005714438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8548703,0.1105068,0.00002922014,0.03179547,0.0001955108,0.001969643,0.00002012869,0.00006225287,0.0005507246],"genre_scores_gemma":[0.976323,0.02005506,0.001394775,0.0008856812,0.0001448966,0.0001385678,0.0001127113,0.00004818963,0.0008971381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1214527,"threshold_uncertainty_score":0.9889616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069549947984226,"score_gpt":0.2448380932074852,"score_spread":0.2341425937276429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}