{"id":"W3202781181","doi":"10.1016/j.molmet.2021.101351","title":"GLP-1 physiology informs the pharmacotherapy of obesity","year":2021,"lang":"en","type":"review","venue":"Molecular Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":469,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Novo Nordisk Fonden; Azrieli Foundation; Israel Science Foundation; Institute of Nutrition, Metabolism and Diabetes; International Development Research Centre","keywords":"Anorectic; Liraglutide; Gastric emptying; Endocrinology; Type 2 diabetes; Glucagon-like peptide-1; Internal medicine; Medicine; Obesity; Insulin; Biology; Diabetes mellitus; Food intake","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080122,0.0005930962,0.0007059974,0.0006232728,0.0002099303,0.001530883,0.0005647888,0.001511993,0.005437908],"category_scores_gemma":[0.001308879,0.0001497494,0.0004225097,0.0004645448,0.0007575633,0.001311306,0.0009164377,0.003319464,0.00205363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005806169,"about_ca_system_score_gemma":0.001231209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005353288,"about_ca_topic_score_gemma":0.0004390627,"domain_scores_codex":[0.9996605,0.00009904186,0.00003097778,0.00005913524,0.0001139153,0.00003647865],"domain_scores_gemma":[0.9995127,0.0001934869,0.00007114631,0.00002268712,0.0001435029,0.00005659004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004182787,0.00006909872,0.0007043333,0.01096577,0.00019122,0.0003230974,0.0001766018,0.001259935,0.01026191,0.03352821,0.07630221,0.8657994],"study_design_scores_gemma":[0.00003460582,0.0002750252,0.001605869,0.004665097,0.0001164559,0.0009429684,0.0001368195,0.0003608029,0.002676689,0.02111325,0.9680403,0.00003195163],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001334902,0.9625461,0.002653235,0.01943003,0.005425441,0.00002224749,0.0001890142,0.00008650797,0.008312535],"genre_scores_gemma":[0.01608427,0.967748,0.001586803,0.005271416,0.005077735,0.00003201518,0.0001541412,0.00002274227,0.004022816],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005437908,"threshold_uncertainty_score":0.01819164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239393645224198,"score_gpt":0.3330863591800766,"score_spread":0.3091469946576568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}