{"id":"W3202792386","doi":"10.2139/ssrn.3909747","title":"c-Mpl-del, an Alternative Splicing Isoform of c-Mpl, Promotes Malignancy and Chemoresistance of AMKL by Regulating AKT/DDIT3 Survival Signaling","year":2021,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Gene isoform; Cancer research; Alternative splicing; Protein kinase B; RNA splicing; Signal transduction; Biology; Medicine; Chemistry; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026387,0.0002309053,0.0001256412,0.0002775373,0.000204519,0.000392087,0.0001685989,0.0002204537,0.001599003],"category_scores_gemma":[0.0001359738,0.0001179216,0.0001706743,0.0001587078,0.0002423821,0.0002149447,0.0001768156,0.0006385171,0.0004926174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003860441,"about_ca_system_score_gemma":0.0001674383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003418201,"about_ca_topic_score_gemma":0.0004930809,"domain_scores_codex":[0.9998645,0.00001648566,0.00001186826,0.00003610096,0.00004265823,0.00002833446],"domain_scores_gemma":[0.9999009,0.00001233316,0.00004323952,0.00001050061,0.00001115208,0.00002178464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489929,0.00002946993,0.001177592,0.00002644806,0.000007089604,0.0002568187,0.00001600124,0.00009147979,0.9944766,0.0002936642,0.0001601837,0.003315601],"study_design_scores_gemma":[0.00004325707,0.0002765227,0.01515765,0.000008713965,0.00003261636,0.002606335,0.00007502532,0.00204839,0.9712223,0.000320939,0.008198854,0.000009310283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931525,0.00134121,0.00218575,0.0002649432,0.00004940172,0.00001705733,0.0003557282,0.0001348291,0.002498651],"genre_scores_gemma":[0.997227,0.0003081704,0.0007202954,0.00005351869,0.0000122804,0.00001019256,0.0002992912,0.0000122696,0.001357057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001599003,"threshold_uncertainty_score":0.005349219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008708786500671781,"score_gpt":0.2615162817056512,"score_spread":0.2528074952049794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}