{"id":"W3202810469","doi":"10.1158/1078-0432.ccr-21-1942","title":"Predictive Significance of an Optimized Panel for Basal-like Breast Cancer: Results from the Canadian Cancer Trials Group MA.5 and MA.12 Phase III Clinical Trials","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Centre for Advancing Health Outcomes; McMaster University Medical Centre; Queen's University; University of British Columbia","funders":"Canadian Cancer Society","keywords":"Breast cancer; Tamoxifen; Anthracycline; Internal medicine; Basal (medicine); Oncology; Medicine; Nestin; Placebo; Chemotherapy; Cancer; Tissue microarray; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01493192,0.001305601,0.002270969,0.0003697015,0.000502719,0.001215259,0.00113597,0.001225969,0.001614277],"category_scores_gemma":[0.01823641,0.0003128988,0.002141991,0.0008638609,0.0007078713,0.0006626103,0.0004930748,0.001665786,0.0002365141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003865238,"about_ca_system_score_gemma":0.005016923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05687399,"about_ca_topic_score_gemma":0.1301439,"domain_scores_codex":[0.99265,0.005135667,0.0002901594,0.0006142316,0.0009357076,0.0003742941],"domain_scores_gemma":[0.989461,0.00469214,0.002463414,0.0008082783,0.001464489,0.001110554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7381083,0.00123724,0.1012122,0.002143516,0.01907429,0.00008936527,0.0002495032,0.00678298,0.005428371,0.0008095364,0.0153918,0.1094729],"study_design_scores_gemma":[0.2503879,0.06900184,0.6112103,0.0007476426,0.02827756,0.0003154759,0.0001664083,0.01265417,0.002859192,0.001369993,0.02273033,0.0002792511],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9220258,0.04973413,0.002325193,0.004627292,0.0002561068,0.002333956,0.01030195,0.0001976803,0.008197992],"genre_scores_gemma":[0.9868451,0.002482787,0.002076353,0.001272732,0.0001631627,0.0009677294,0.005260506,0.00002999861,0.0009015866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05687399,"threshold_uncertainty_score":0.1130859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4181984858538448,"score_gpt":0.5558475683230675,"score_spread":0.1376490824692226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}