{"id":"W3202815206","doi":"10.1038/s41586-021-03911-7","title":"Structure-based classification of tauopathies","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":919,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Rossy Foundation; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; National Center of Neurology and Psychiatry; National Institutes of Health; University of Cambridge; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Biotechnology and Biological Sciences Research Council; School of Medicine, Indiana University; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Diamond Light Source; Wellcome Trust; Japan Agency for Medical Research and Development","keywords":"Tauopathy; Corticobasal degeneration; Progressive supranuclear palsy; Tau protein; Neuropathology; Tangle; Neuroscience; Biology; Pathology; Alzheimer's disease; Medicine; Neurodegeneration; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007382069,0.0005519186,0.0006200387,0.00459556,0.0008753055,0.001934474,0.0007594574,0.0009618098,0.002517398],"category_scores_gemma":[0.002527335,0.0001866875,0.001039123,0.001477859,0.0005830006,0.001319737,0.0007413758,0.0007864157,0.00127453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001062571,"about_ca_system_score_gemma":0.0008477446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002144177,"about_ca_topic_score_gemma":0.003244272,"domain_scores_codex":[0.9995695,0.00007028999,0.00004089841,0.00009972374,0.0001400142,0.00007966685],"domain_scores_gemma":[0.9984079,0.000289276,0.0003578062,0.0002290401,0.0005268452,0.0001891881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003164936,0.0006185976,0.324281,0.001128376,0.0006275525,0.00163609,0.001107489,0.02619407,0.1916158,0.04768389,0.02685377,0.3750885],"study_design_scores_gemma":[0.0002632294,0.00132787,0.3315649,0.0005880489,0.001116158,0.008136518,0.001252595,0.3690353,0.04786803,0.1723705,0.06630424,0.0001726902],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8946694,0.009115223,0.06097112,0.001548264,0.0004523401,0.0002598701,0.006081804,0.001298598,0.02560342],"genre_scores_gemma":[0.9425436,0.001960434,0.04309396,0.0002252807,0.0001701481,0.00007781736,0.008581514,0.0001814435,0.003165814],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00459556,"threshold_uncertainty_score":0.00842154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025027538168114,"score_gpt":0.3295453138556741,"score_spread":0.309295038473993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}