{"id":"W3202817459","doi":"10.3390/antibiotics10101164","title":"Pseudomonas aeruginosa mexR and mexEF Antibiotic Efflux Pump Variants Exhibit Increased Virulence","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Efflux; Virulence; Pseudomonas aeruginosa; Rhamnolipid; Microbiology; Biology; Virulence factor; Pyocyanin; Antibiotic resistance; Swarming motility; Antibiotics; Gene; Bacteria; Genetics; Quorum sensing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604165,0.0003350887,0.0003541869,0.0002304628,0.0001209935,0.0002686001,0.0001355178,0.0004576249,0.001404782],"category_scores_gemma":[0.0002690397,0.0001371642,0.0002522988,0.0001499705,0.0002001644,0.0001581686,0.0002399581,0.0005933509,0.000339817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001516087,"about_ca_system_score_gemma":0.0001107786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003248165,"about_ca_topic_score_gemma":0.000395813,"domain_scores_codex":[0.9997072,0.00007348327,0.00003016199,0.00004134905,0.00009654441,0.00005135431],"domain_scores_gemma":[0.9998087,0.00003378139,0.00006606226,0.00002537474,0.00002242461,0.00004366591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006893837,0.00002532963,0.0003792846,0.00001628132,0.000004689686,0.00009652819,0.000009179885,0.00002403957,0.9983922,0.00003483699,0.000045462,0.0009032675],"study_design_scores_gemma":[0.00005398599,0.001576067,0.07004605,0.00001607183,0.00004027466,0.004044294,0.0001064315,0.001281689,0.9184976,0.0001451493,0.004165461,0.00002698629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961466,0.001050131,0.001186309,0.0002817153,0.00002125148,0.00001490118,0.0002677743,0.00006852495,0.0009628142],"genre_scores_gemma":[0.9966019,0.0004196068,0.00101748,0.0001221869,0.00001025116,0.00002069353,0.000280525,0.00003036161,0.00149697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404782,"threshold_uncertainty_score":0.004699469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008428579753804446,"score_gpt":0.2372782253917004,"score_spread":0.2288496456378959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}