{"id":"W3202817459","doi":"10.3390/antibiotics10101164","title":"Pseudomonas aeruginosa mexR and mexEF Antibiotic Efflux Pump Variants Exhibit Increased Virulence","year":2021,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Efflux; Virulence; Pseudomonas aeruginosa; Rhamnolipid; Microbiology; Biology; Virulence factor; Pyocyanin; Antibiotic resistance; Swarming motility; Antibiotics; Gene; Bacteria; Genetics; Quorum sensing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003232442,0.0004261217,0.0004493005,0.00006892978,0.0002162679,0.0001660255,0.0003420003,0.0004037944,0.00007800382],"category_scores_gemma":[0.0004517728,0.0004395167,0.0001392087,0.0002811652,0.0003649927,0.00002066279,0.0004127136,0.0002153659,0.00007648036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002652054,"about_ca_system_score_gemma":0.0002634956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000508179,"about_ca_topic_score_gemma":0.00006403927,"domain_scores_codex":[0.9973847,0.0001863782,0.0004853899,0.0009965481,0.0003107057,0.0006362882],"domain_scores_gemma":[0.9982384,0.00006702901,0.0001885974,0.001003954,0.0002410047,0.0002609727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000528369,0.0001724006,0.1190356,0.0001207848,0.0001278982,0.0001606519,0.0000293436,0.000004660133,0.8779049,0.0007748243,0.001091168,0.0005249652],"study_design_scores_gemma":[0.0009000328,0.0001573683,0.1570216,0.0001574642,0.0001046038,0.0003014905,0.0001281135,0.0001059267,0.8364141,0.0001170805,0.004023162,0.0005690845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938971,0.001004705,0.001326455,0.0002272289,0.000484956,0.0002241283,0.00007826616,0.00004880609,0.002708393],"genre_scores_gemma":[0.9892805,0.002121795,0.006136534,0.0006782002,0.000352726,2.119467e-7,0.0002313238,0.00007143876,0.00112723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04149077,"threshold_uncertainty_score":0.9998057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008428579753804446,"score_gpt":0.2372782253917004,"score_spread":0.2288496456378959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}