{"id":"W3202865010","doi":"10.1016/j.isci.2021.103169","title":"Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum","year":2021,"lang":"en","type":"article","venue":"iScience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Tyrosine hydroxylase; Epigenetics; Methylation; Nucleus accumbens; DNA methylation; Striatum; Dopaminergic; Biology; FOSB; Dopamine; Gene; Transcription factor; Endocrinology; Internal medicine; Genetics; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000585142,0.00009600743,0.0001756392,0.0003068899,0.000148936,0.0001610228,0.00007552995,0.0001338471,0.000741177],"category_scores_gemma":[0.000176418,0.00009326183,0.00006924435,0.0001643335,0.0001284865,0.00003611881,0.0001183869,0.0001145671,0.00007695294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001394556,"about_ca_system_score_gemma":0.0001108646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004239592,"about_ca_topic_score_gemma":0.008329324,"domain_scores_codex":[0.9999442,0.00001135036,0.000003087034,0.00002048693,0.00001365601,0.000007158907],"domain_scores_gemma":[0.9999422,0.000006151432,0.00002353044,0.000004108282,0.00001233172,0.00001177846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000788959,0.00005471345,0.2881143,0.00004882176,0.0001850572,0.0005937665,0.000378542,0.0001985499,0.699495,0.0001075165,0.0001813663,0.00985351],"study_design_scores_gemma":[0.000007399994,0.0001175405,0.9813265,0.000005881307,0.00004184505,0.001098867,0.0001055669,0.0004693578,0.01641553,0.00007894516,0.0003284815,0.00000408375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992833,0.0002249908,0.000167616,0.00001286025,0.00000102556,0.000002048277,0.00009308491,0.000003721603,0.0002114829],"genre_scores_gemma":[0.9993564,0.0001344078,0.0001416381,0.000008835598,8.88233e-7,0.000002207101,0.0001136557,0.000002401356,0.0002395772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004239592,"threshold_uncertainty_score":0.008429825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341919226931495,"score_gpt":0.2725005422313617,"score_spread":0.2590813499620467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}