{"id":"W3202885034","doi":"10.1016/j.annonc.2021.08.1257","title":"815TiP ENGOT/GYN1/NCRI: ATR inhibitor in combination with olaparib in gynaecological cancers with ARID1A loss or no loss (ATARI)","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Cilag; Sun Pharma; Puma Biotechnology; Pfizer; Clovis Oncology; Merck KGaA; Mersana Therapeutics; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Olaparib; ARID1A; Oncology; Cancer research; Internal medicine; Mutation; Genetics; Gene; Poly ADP ribose polymerase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002580549,0.0003182507,0.0008222461,0.0003357859,0.0002483975,0.0004401733,0.0005419778,0.0004692466,0.005533656],"category_scores_gemma":[0.0003242494,0.0001549674,0.0004848791,0.0003156363,0.0002855138,0.0002547556,0.0002560499,0.001286707,0.001000722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205372,"about_ca_system_score_gemma":0.0005902137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005160644,"about_ca_topic_score_gemma":0.001713733,"domain_scores_codex":[0.9998733,0.00002738756,0.00001538658,0.00002262832,0.00001864045,0.00004273198],"domain_scores_gemma":[0.9998933,0.00002181714,0.00001379133,0.00001397821,0.000006535941,0.00005055439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1166749,0.008220195,0.006234881,0.001804094,0.001370992,0.002908353,0.0002985944,0.002849169,0.3109068,0.002381621,0.02966856,0.5166818],"study_design_scores_gemma":[0.1200891,0.161487,0.07618489,0.0006228421,0.003273128,0.02097058,0.0006746961,0.01056239,0.3685812,0.002261369,0.2349262,0.0003664944],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9591571,0.01983386,0.0008607151,0.001569492,0.0009530029,0.0003377311,0.001442855,0.0005071407,0.01533795],"genre_scores_gemma":[0.9863804,0.004708423,0.002025248,0.0005737043,0.0001623694,0.0001798834,0.001424454,0.00003490382,0.004510572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005533656,"threshold_uncertainty_score":0.01851195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323255688165161,"score_gpt":0.3242393482886152,"score_spread":0.2919137794720991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}