{"id":"W3202924187","doi":"10.1093/neuonc/noab235","title":"DNA methylation-based prognostic subtypes of chordoma tumors in tissue and plasma","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Beijing Municipal Science and Technology Commission; Canada Research Chairs; Terry Fox Research Institute; Canadian Cancer Society; National Institutes of Health; Ontario Institute for Cancer Research; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"DNA methylation; Chordoma; Methylation; Cancer research; DNA; Biology; Pathology; Medicine; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009235634,0.0001114662,0.0004194348,0.0001102144,0.00002135854,0.000004399628,0.00003062548,0.00008177503,0.0001441432],"category_scores_gemma":[0.0005742392,0.0001006956,0.00003448195,0.000226062,0.00007955777,0.00002621141,0.00002617602,0.0001335878,0.00001811328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005903906,"about_ca_system_score_gemma":0.0003278298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004821136,"about_ca_topic_score_gemma":0.0002147056,"domain_scores_codex":[0.9990425,0.0001361735,0.0002766994,0.0002617666,0.0001144082,0.0001684384],"domain_scores_gemma":[0.9986635,0.0009229371,0.00009487272,0.0001557952,0.0000751504,0.00008772987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002194607,0.001251207,0.7739235,0.0001116271,0.00003357728,0.003456532,0.0001500342,0.00001883259,0.1861076,0.0001952723,0.0002012779,0.03433104],"study_design_scores_gemma":[0.004871184,0.001935939,0.6259036,0.00008238234,0.0001360171,0.0002496263,0.00005716322,0.0003032995,0.3557984,0.00009739566,0.01047402,0.00009101626],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948,0.0004677668,0.00000382893,0.002595733,0.0001137188,0.0003333973,0.000007398633,0.00001883085,0.001659286],"genre_scores_gemma":[0.9987425,0.00005519639,0.0006111056,0.0004087305,0.00003070204,0.00005823843,0.00002797796,0.00001657778,0.00004899757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1696908,"threshold_uncertainty_score":0.4106247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01921135623655127,"score_gpt":0.3015004792846447,"score_spread":0.2822891230480934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}