{"id":"W3202958967","doi":"10.7554/elife.69198","title":"A sex-specific evolutionary interaction between ADCY9 and CETP","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut de Cardiologie de Montréal; Université de Montréal; Canada Research Chairs; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"Cholesterylester transfer protein; Biology; Genetics; Single-nucleotide polymorphism; Linkage disequilibrium; Population; Locus (genetics); Epistasis; Gene; Computational biology; Genotype; Medicine; Cholesterol; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003825423,0.0002485842,0.0001915199,0.0003958506,0.0003070904,0.0003011513,0.000193171,0.0003627017,0.005123868],"category_scores_gemma":[0.001137213,0.0001268254,0.0003116142,0.0004866461,0.0002197498,0.0001307219,0.0003386911,0.0004068592,0.0002792226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001088892,"about_ca_system_score_gemma":0.0001223404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001921817,"about_ca_topic_score_gemma":0.002657435,"domain_scores_codex":[0.9996827,0.00009134605,0.00001598383,0.0001345647,0.00003543761,0.00004006981],"domain_scores_gemma":[0.9996087,0.0001611689,0.0001224784,0.00004280954,0.0000274782,0.00003728637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001257888,0.00004269589,0.9118879,0.000108757,0.0006857958,0.001522097,0.0005156115,0.0002101746,0.05516526,0.0008938013,0.0007840655,0.02692595],"study_design_scores_gemma":[0.00003117396,0.0001465006,0.992388,0.00001409111,0.0001457659,0.001523667,0.0001246768,0.0003703555,0.002296953,0.0004430133,0.002506323,0.000009370071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939382,0.001298049,0.00188143,0.0004917434,0.00001950948,0.000009576652,0.0007844609,0.00002910661,0.001547838],"genre_scores_gemma":[0.9976195,0.0003236623,0.0005957253,0.0001197465,0.00001946444,0.000006963385,0.0003334954,0.00001190253,0.000969624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005123868,"threshold_uncertainty_score":0.01714098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073281276110679,"score_gpt":0.277450218333178,"score_spread":0.2567174055720712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}