{"id":"W3202968128","doi":"10.1126/scitranslmed.abc0497","title":"Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; EMD Serono; National Institutes of Health; University of California, San Francisco; Robert Connor Dawes Foundation; Cancer Research UK; Incyte; CERN; Rudi Schulte Research Institute; Children's Hospital Los Angeles; Ian's Friends Foundation; Amgen; A. Alfred Taubman Medical Research Institute; AstraZeneca; Pfizer; Hyundai Hope On Wheels; Damon Runyon Cancer Research Foundation","keywords":"Epigenetics; Metabolic pathway; Ependymoma; Biology; Cancer research; Epigenesis; Posterior fossa; Medicine; Bioinformatics; Neuroscience; Computational biology; Genetics; DNA methylation; Pathology; Gene; Anatomy; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007678668,0.000119594,0.0001494377,0.000120718,0.0001170372,0.00001726576,0.0001195503,0.00005616174,0.00005924872],"category_scores_gemma":[0.000387249,0.0001030219,0.00002298387,0.0005402705,0.0003813098,0.0000104578,0.00003025862,0.00010347,0.000001740894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006363065,"about_ca_system_score_gemma":0.0003321011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003234103,"about_ca_topic_score_gemma":0.00005583007,"domain_scores_codex":[0.9986677,0.00006556162,0.000270409,0.0004271556,0.0003352862,0.0002338526],"domain_scores_gemma":[0.9994985,0.00003259415,0.00004771676,0.0001438862,0.0001690799,0.0001081548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007649107,0.00003224325,0.01198284,0.000005079134,0.000005530146,0.000007804835,0.0004017461,0.0004392916,0.9754561,0.001161405,0.00000375512,0.01049657],"study_design_scores_gemma":[0.00133545,0.0001428987,0.4675888,0.00005427152,0.00001948096,0.00002468988,0.0004103716,0.001419126,0.5205327,0.005403904,0.002822604,0.0002457615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737896,0.01824265,0.005198034,0.001340484,0.0001682533,0.0001151642,0.00001013442,0.000006392094,0.001129258],"genre_scores_gemma":[0.9951704,0.0007678564,0.00359213,0.0001090466,0.0001669895,0.000007034272,0.0001419278,0.000008910375,0.00003574577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4556059,"threshold_uncertainty_score":0.420111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435681915740654,"score_gpt":0.2647359861430035,"score_spread":0.250379166985597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}