{"id":"W3202968128","doi":"10.1126/scitranslmed.abc0497","title":"Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; BC Children's Hospital; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; EMD Serono; National Institutes of Health; University of California, San Francisco; Robert Connor Dawes Foundation; Cancer Research UK; Incyte; CERN; Rudi Schulte Research Institute; Children's Hospital Los Angeles; Ian's Friends Foundation; Amgen; A. Alfred Taubman Medical Research Institute; AstraZeneca; Pfizer; Hyundai Hope On Wheels; Damon Runyon Cancer Research Foundation","keywords":"Epigenetics; Metabolic pathway; Ependymoma; Biology; Cancer research; Epigenesis; Posterior fossa; Medicine; Bioinformatics; Neuroscience; Computational biology; Genetics; DNA methylation; Pathology; Gene; Anatomy; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007391338,0.0002081427,0.0001849591,0.0001957245,0.0001152474,0.0001393099,0.000114511,0.000151095,0.0007016891],"category_scores_gemma":[0.00007099902,0.00006927975,0.0001181962,0.0001471471,0.0001784419,0.0001365493,0.0001390813,0.0003839587,0.0000821414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002092112,"about_ca_system_score_gemma":0.0001696617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005552414,"about_ca_topic_score_gemma":0.001463594,"domain_scores_codex":[0.9999574,0.00000409079,0.000003944665,0.000009672983,0.00001243512,0.00001241827],"domain_scores_gemma":[0.9999717,0.000005277388,0.000009127435,0.000002945548,0.000002423533,0.000008461817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002037105,0.00003109523,0.001236549,0.0000390039,0.00001230428,0.0004957523,0.00001639175,0.0002315737,0.9883403,0.000223688,0.00005768065,0.009112017],"study_design_scores_gemma":[0.00003891614,0.0006168892,0.02243618,0.000007517606,0.00003400326,0.00309033,0.00006122882,0.00112735,0.969321,0.0001852788,0.003075172,0.000006250361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957628,0.0007067559,0.002391589,0.00006772106,0.00001530711,0.00001696804,0.0001842551,0.00004184582,0.0008126926],"genre_scores_gemma":[0.9972579,0.0006053461,0.001238984,0.00001988423,0.000003406244,0.00001473359,0.0001549579,0.000005940114,0.0006987387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007016891,"threshold_uncertainty_score":0.00234741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435681915740654,"score_gpt":0.2647359861430035,"score_spread":0.250379166985597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}