{"id":"W3202975952","doi":"10.1002/pro.4196","title":"Structure‐based design of a photoswitchable affibody scaffold","year":2021,"lang":"en","type":"article","venue":"Protein Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Chemistry; Protein engineering; Biophysics; Chimera (genetics); Protein design; Mutant; Reagent; Protein structure; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771729,0.0005124359,0.0002922628,0.0002444471,0.0002145643,0.0003998648,0.0006042286,0.0004563696,0.0008521415],"category_scores_gemma":[0.0001544108,0.0002119694,0.0003482845,0.000202427,0.0002323097,0.0003503581,0.0002670618,0.0006461011,0.0006698106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005827895,"about_ca_system_score_gemma":0.0003200837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003996784,"about_ca_topic_score_gemma":0.0003673632,"domain_scores_codex":[0.9998863,0.00001387941,0.00001322095,0.00003137071,0.00002819582,0.000027],"domain_scores_gemma":[0.9999213,0.00001047516,0.00002218146,0.000008774004,0.00001484485,0.00002231654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004955498,0.00004533871,0.00008051902,0.00004504633,0.000005840532,0.000095266,0.00002210435,0.001963239,0.9934537,0.0006826184,0.00005318527,0.003503565],"study_design_scores_gemma":[0.0000250112,0.0002986029,0.0002139714,0.000003493532,0.000009958982,0.0001347659,0.00001336142,0.004692755,0.9914262,0.0001128078,0.003060476,0.000008501213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8763081,0.0009330986,0.1163373,0.0002704042,0.00008030464,0.0003456619,0.0004422977,0.0007385554,0.004544141],"genre_scores_gemma":[0.9266261,0.0006942838,0.06799822,0.0001442562,0.00001666948,0.0002525115,0.0005736367,0.00005047052,0.003643822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008521415,"threshold_uncertainty_score":0.004228413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07027448237405587,"score_gpt":0.3286231913022468,"score_spread":0.258348708928191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}