{"id":"W3202975952","doi":"10.1002/pro.4196","title":"Structure‐based design of a photoswitchable affibody scaffold","year":2021,"lang":"en","type":"article","venue":"Protein Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Chemistry; Protein engineering; Biophysics; Chimera (genetics); Protein design; Mutant; Reagent; Protein structure; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006702138,0.0001263457,0.0001618107,0.0001914473,0.0002704706,0.0001340484,0.0009292501,0.00004467,0.0006063594],"category_scores_gemma":[0.001969074,0.0001118956,0.00004532775,0.002345267,0.0009013527,0.000215208,0.0002364836,0.0001323937,0.0000274298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006124053,"about_ca_system_score_gemma":0.00144241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001853411,"about_ca_topic_score_gemma":0.000002843668,"domain_scores_codex":[0.9970915,0.0001654727,0.0002082244,0.0006604928,0.001327125,0.0005472045],"domain_scores_gemma":[0.9987244,0.000153059,0.00008170095,0.0005599391,0.000284134,0.000196774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002542446,0.00006004675,0.0000649322,0.000021887,5.583215e-7,0.00001307866,0.00006910228,0.0008444606,0.9977826,0.0004670956,0.0000125616,0.0006382748],"study_design_scores_gemma":[0.000239278,0.00009839889,0.00006983914,0.00003007418,0.000001537051,0.00000764186,0.00001446813,0.02129562,0.976757,0.0011536,0.0002059177,0.0001266168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814223,0.00008709241,0.01473727,0.0001074189,0.0001534648,0.0008137444,0.00002884141,0.00004505727,0.002604784],"genre_scores_gemma":[0.9863177,0.000006651242,0.01321534,0.0001271638,0.00001863738,0.00004389757,4.783028e-7,0.00001169392,0.0002584272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02102557,"threshold_uncertainty_score":0.663921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07027448237405587,"score_gpt":0.3286231913022468,"score_spread":0.258348708928191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}