{"id":"W3203009579","doi":"10.1371/journal.ppat.1009991","title":"Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Neurodegeneration; PDK4; Biology; Pyruvate dehydrogenase complex; Oxidative phosphorylation; Citric acid cycle; Cell biology; Metabolome; Mitochondrion; Oxidative stress; Glycolysis; Biochemistry; Metabolism; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090919,0.0001306893,0.0002882313,0.00005414795,0.00002050295,0.000005563919,0.0001118156,0.00009595919,0.00001054842],"category_scores_gemma":[0.0003284111,0.0001295487,0.0001447066,0.0001246355,0.00005071404,0.000008137593,0.00007557809,0.00004845378,3.213538e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006535273,"about_ca_system_score_gemma":0.0002055194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000602722,"about_ca_topic_score_gemma":0.000008820953,"domain_scores_codex":[0.9988192,0.0001483005,0.0004039058,0.0002841714,0.0001936219,0.0001508103],"domain_scores_gemma":[0.9991029,0.00001031349,0.0002372746,0.0003373229,0.00025038,0.00006181207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001905157,0.0004794054,0.003563361,0.0002436051,0.00004321525,0.000004474475,0.00004538476,0.0025103,0.989054,0.0002134738,0.000001864669,0.003650393],"study_design_scores_gemma":[0.0008482996,0.0001093214,0.003100088,0.00008477003,0.00008297001,0.000001072414,0.00001352478,0.01163924,0.9836996,0.0002810961,0.00002456834,0.0001155075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822546,0.01312688,0.003561805,0.00005410392,0.00001968108,0.000517407,0.0004519148,0.000005086342,0.000008504052],"genre_scores_gemma":[0.9971618,0.001077231,0.00146214,0.00002532076,0.00004385924,0.0000576266,0.0001406307,0.00001848655,0.00001289974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01490719,"threshold_uncertainty_score":0.5282843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140313547638374,"score_gpt":0.2222310600748727,"score_spread":0.210827924598489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}