{"id":"W3203009579","doi":"10.1371/journal.ppat.1009991","title":"Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Neurodegeneration; PDK4; Biology; Pyruvate dehydrogenase complex; Oxidative phosphorylation; Citric acid cycle; Cell biology; Metabolome; Mitochondrion; Oxidative stress; Glycolysis; Biochemistry; Metabolism; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517984,0.0004725311,0.0004012802,0.0004389474,0.0002372959,0.0002999616,0.0002359501,0.0003711193,0.001216384],"category_scores_gemma":[0.0001078436,0.0001700919,0.00033561,0.0003033121,0.0003782147,0.0002628767,0.0002291606,0.001451318,0.0002868068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310396,"about_ca_system_score_gemma":0.000217072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009999884,"about_ca_topic_score_gemma":0.001083411,"domain_scores_codex":[0.9998236,0.00002548491,0.00002187942,0.00004560053,0.00003701083,0.00004631992],"domain_scores_gemma":[0.9998412,0.00001391691,0.00005008546,0.00001954872,0.00001670647,0.00005860735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008948476,0.0003767647,0.0005010498,0.00008350224,0.00001865233,0.0002314668,0.00006275328,0.0001234922,0.9958776,0.0001664479,0.0001688915,0.0014944],"study_design_scores_gemma":[0.0001168505,0.002964161,0.01435119,0.00003683643,0.00007249224,0.0007199691,0.0001462557,0.002908895,0.9750119,0.0002818117,0.00336565,0.00002391936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937685,0.001871007,0.001847598,0.0001904482,0.0001073678,0.0000601763,0.0006825154,0.0001366838,0.001335793],"genre_scores_gemma":[0.9920561,0.001622719,0.001666527,0.0000850859,0.00002124749,0.00020575,0.0007888549,0.00002936676,0.003524357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216384,"threshold_uncertainty_score":0.004069209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140313547638374,"score_gpt":0.2222310600748727,"score_spread":0.210827924598489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}