{"id":"W3203015639","doi":"10.3389/fphys.2021.727806","title":"Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma","year":2021,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; ARDS; COPD; Medicine; Asthma; Pulmonary fibrosis; Immunology; Transcription factor; Lung; Respiratory disease; Respiratory distress; Fibrosis; Bioinformatics; Pathology; Biology; Internal medicine; Biochemistry; Anesthesia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000107242,0.0004522492,0.001319573,0.0001547447,0.00002176596,0.00000799656,0.0003823718,0.0003750669,0.000004664112],"category_scores_gemma":[0.00004880097,0.0004386276,0.0003303887,0.0001614714,0.0002601404,0.000003198387,0.0003396695,0.0002580789,5.983757e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003718043,"about_ca_system_score_gemma":0.0002473242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005152254,"about_ca_topic_score_gemma":0.000001980887,"domain_scores_codex":[0.9978502,0.0002542723,0.0004931203,0.000927317,0.00009658007,0.0003785414],"domain_scores_gemma":[0.9989656,0.00001918756,0.0002445485,0.0005914517,0.00003217115,0.0001470682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005652874,0.002182187,0.0007188345,0.01860676,0.001105901,0.00008295198,0.0001281109,0.0002839875,0.4232596,0.003404546,0.0002052452,0.5494565],"study_design_scores_gemma":[0.00318356,0.0005085247,0.0147373,0.01005932,0.00169151,0.00004675569,0.001089536,0.001423079,0.0128708,0.07045402,0.8786818,0.005253735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003260593,0.9945291,0.001194993,0.00001382863,0.0001744882,0.0005247549,0.0002470344,0.000004399953,0.00005086653],"genre_scores_gemma":[0.03372227,0.9621924,0.001920367,0.00005868286,0.00009927338,0.0002318511,0.001668735,0.00007078503,0.00003568134],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8784766,"threshold_uncertainty_score":0.9998065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893076499855344,"score_gpt":0.2490005771932784,"score_spread":0.2300698121947249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}