{"id":"W3203015639","doi":"10.3389/fphys.2021.727806","title":"Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma","year":2021,"lang":"en","type":"review","venue":"Frontiers in Physiology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; ARDS; COPD; Medicine; Asthma; Pulmonary fibrosis; Immunology; Transcription factor; Lung; Respiratory disease; Respiratory distress; Fibrosis; Bioinformatics; Pathology; Biology; Internal medicine; Biochemistry; Anesthesia; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128075,0.0005166967,0.000881004,0.0006953292,0.0002626244,0.0007170365,0.0004551848,0.0008141944,0.003906901],"category_scores_gemma":[0.0001745899,0.0001381577,0.0004160485,0.0005169743,0.0004374097,0.001055664,0.0005092189,0.001457544,0.001526035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004436238,"about_ca_system_score_gemma":0.0005444221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002461131,"about_ca_topic_score_gemma":0.0006379268,"domain_scores_codex":[0.9999003,0.00002325768,0.00001082412,0.00002087397,0.00002582197,0.00001876196],"domain_scores_gemma":[0.9999312,0.00001781456,0.00001125335,0.000004390241,0.00002351407,0.00001187801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005235467,0.0002635613,0.0005740474,0.02410886,0.0002026323,0.0009376453,0.0002677138,0.0007089503,0.06995606,0.02721426,0.04390037,0.8313423],"study_design_scores_gemma":[0.00004203587,0.0004751687,0.002221438,0.001920269,0.0001354459,0.002498802,0.0001549949,0.0003148928,0.008746431,0.01387606,0.9695725,0.00004186472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00147373,0.9912976,0.00135228,0.00236505,0.0006823592,0.00001467766,0.00007583092,0.00004671932,0.002691768],"genre_scores_gemma":[0.013294,0.9808668,0.001192355,0.0009118553,0.0007687805,0.00002713625,0.0001494973,0.000008536244,0.002781129],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003906901,"threshold_uncertainty_score":0.01306993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893076499855344,"score_gpt":0.2490005771932784,"score_spread":0.2300698121947249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}