{"id":"W3203049323","doi":"10.1186/s12964-021-00778-z","title":"CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner","year":2021,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"SDHA; Biology; Cell biology; Mitochondrion; Biochemistry; Glycolysis; Oxidative phosphorylation; Protein kinase A; Citric acid cycle; Kinase; Metabolic pathway; Metabolism; Succinate dehydrogenase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002156551,0.0001546794,0.0001808359,0.00005274319,0.0002427601,0.0000780508,0.000114499,0.0001506746,0.00002854643],"category_scores_gemma":[0.00002364276,0.0001658949,0.00004887237,0.0001123414,0.00005798599,0.00002517181,0.00007035486,0.00015464,0.000001259277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001094086,"about_ca_system_score_gemma":0.00006685279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004796716,"about_ca_topic_score_gemma":0.00005232125,"domain_scores_codex":[0.9988467,0.0002550898,0.0002565223,0.0003591376,0.0001153544,0.0001671912],"domain_scores_gemma":[0.9991001,0.00006651137,0.0001222606,0.000400026,0.0002277201,0.00008337417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002824379,0.00009270858,0.0001078525,0.00002232724,0.00001139613,2.873834e-7,0.000190912,0.0007482184,0.9969899,0.00005214349,0.000660484,0.000841348],"study_design_scores_gemma":[0.001860708,0.00003532455,0.0006917831,0.00002436734,0.00002553808,0.000004776755,0.0002379902,0.00213513,0.9590938,0.0001499966,0.03553179,0.0002087936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9479311,0.04652557,0.004734099,0.0002356122,0.0001679155,0.0001922098,0.00002183271,0.0000124946,0.0001791965],"genre_scores_gemma":[0.9922029,0.005339956,0.00115366,0.0001147308,0.0001668156,0.00002421595,0.0006573388,0.00001981809,0.0003206061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04427179,"threshold_uncertainty_score":0.6764997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334119967372361,"score_gpt":0.2354970918525629,"score_spread":0.2221558921788393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}