{"id":"W3203112082","doi":"10.1002/dvdy.427","title":"A <scp>CRISPR</scp>/Cas9 zebrafish lamin A/C mutant model of muscular laminopathy","year":2021,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"LMNA; Zebrafish; Biology; Skeletal muscle; Mutant; Lamin; Cell biology; CRISPR; Molecular biology; Genetics; Gene; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598032,0.0008047102,0.0004785207,0.0009162147,0.00061864,0.0003359903,0.0007794775,0.001224583,0.00606314],"category_scores_gemma":[0.0001234962,0.0003376125,0.0005251614,0.0002611405,0.0007751546,0.000335517,0.0003665476,0.001189725,0.001671394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008798421,"about_ca_system_score_gemma":0.0008863862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003880468,"about_ca_topic_score_gemma":0.006823848,"domain_scores_codex":[0.9996662,0.00001893879,0.00003462154,0.00009710566,0.0001330038,0.00005011014],"domain_scores_gemma":[0.9997333,0.00002436983,0.0001011154,0.00002383868,0.00002801494,0.00008946665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007710636,0.00004182121,0.0001168073,0.00004563955,0.000006984881,0.0002495776,0.00001851571,0.0001216018,0.9981428,0.0002415359,0.0002104661,0.0007270768],"study_design_scores_gemma":[0.00009437229,0.0007131735,0.004409383,0.00003118595,0.00006120757,0.001948837,0.00005488301,0.002557624,0.9810408,0.0001672818,0.008888454,0.00003284313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478751,0.0009542927,0.03212878,0.0008138712,0.0002722409,0.0005950446,0.006042899,0.00296587,0.008351862],"genre_scores_gemma":[0.9144319,0.001004522,0.03563271,0.0002600017,0.00003694078,0.0009179736,0.003766979,0.000409364,0.04353955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00606314,"threshold_uncertainty_score":0.02028322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005952028732717551,"score_gpt":0.1952072155916725,"score_spread":0.1892551868589549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}