{"id":"W3203112082","doi":"10.1002/dvdy.427","title":"A <scp>CRISPR</scp>/Cas9 zebrafish lamin A/C mutant model of muscular laminopathy","year":2021,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"LMNA; Zebrafish; Biology; Skeletal muscle; Mutant; Lamin; Cell biology; CRISPR; Molecular biology; Genetics; Gene; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000848601,0.0001788773,0.0001798322,0.00004217741,0.00006976414,0.00002001769,0.0001367761,0.0001872136,0.00001269105],"category_scores_gemma":[0.00008289256,0.000188338,0.0001038568,0.0001411395,0.00005779111,0.000006795584,0.0001868064,0.0001031038,0.00001050732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005604017,"about_ca_system_score_gemma":0.000191215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007465199,"about_ca_topic_score_gemma":0.0001234478,"domain_scores_codex":[0.9989409,0.00002894495,0.0002564116,0.0003532666,0.000180702,0.0002398028],"domain_scores_gemma":[0.9994878,0.000008433009,0.00008250687,0.0002334122,0.0001179152,0.00006989231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001712078,0.0000972154,0.003991609,0.00005648818,0.0001260818,0.00003589019,0.0002658655,0.0004560218,0.988415,0.00105862,0.001099275,0.004380817],"study_design_scores_gemma":[0.001514525,0.000212128,0.01580952,0.00004978171,0.00008786476,0.0003381834,0.002504827,0.0515012,0.9054756,0.0009395502,0.02116849,0.0003982913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829656,0.0001220181,0.01066221,0.00002275588,0.0002226158,0.00009646408,0.0000949087,0.00001704951,0.005796331],"genre_scores_gemma":[0.982305,0.0001062365,0.0141694,0.0003123268,0.00005719001,0.00000780131,0.0009253466,0.00003944401,0.00207726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08293936,"threshold_uncertainty_score":0.7680202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005952028732717551,"score_gpt":0.1952072155916725,"score_spread":0.1892551868589549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}