{"id":"W3203163864","doi":"10.1016/j.annonc.2021.08.1062","title":"540P Safety and efficacy from the SURPASS trial with ADP-A2M4CD8, a SPEAR T-cell therapy incorporating a CD8α co-receptor and an affinity optimized TCR targeting MAGE-A4","year":2021,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; T-cell receptor; Spear; CD8; Receptor; Oncology; Pharmacology; Immunology; Internal medicine; T cell; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007692182,0.0008036742,0.001186516,0.0001983661,0.0002570287,0.001343683,0.0003084718,0.000900753,0.008119945],"category_scores_gemma":[0.0007092425,0.000255412,0.001078552,0.00019143,0.0005154836,0.000775697,0.0002555594,0.003166337,0.001830784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008563918,"about_ca_system_score_gemma":0.0007505324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009916561,"about_ca_topic_score_gemma":0.001830163,"domain_scores_codex":[0.9997478,0.00006975078,0.00001150781,0.00005220108,0.00004200523,0.00007668139],"domain_scores_gemma":[0.9996809,0.0000785981,0.00004248793,0.0000383523,0.00002124808,0.0001384475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6375088,0.006582603,0.003890579,0.00112987,0.002226494,0.0004991954,0.0002385864,0.005344539,0.07068389,0.003175842,0.02305531,0.2456643],"study_design_scores_gemma":[0.4031962,0.4255508,0.04335782,0.0002805909,0.003207493,0.002426495,0.0002039797,0.005694935,0.03379084,0.004982171,0.07712229,0.0001863976],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.969522,0.00534064,0.001682175,0.002045634,0.000379047,0.0004579088,0.005442115,0.000299786,0.01483065],"genre_scores_gemma":[0.9753829,0.002612634,0.0006755136,0.001317718,0.0001663285,0.0003411336,0.005761222,0.00009720249,0.01364542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008119945,"threshold_uncertainty_score":0.02716392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09642382633896207,"score_gpt":0.3983337409566994,"score_spread":0.3019099146177374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}