{"id":"W3203166965","doi":"10.1136/jitc-2021-003329","title":"CXCR6 by increasing retention of memory CD8<sup>+</sup> T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer","year":2021,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; NIH Office of the Director","keywords":"Immunosurveillance; Ovarian cancer; Tumor microenvironment; CD8; Cytotoxic T cell; Cancer research; Medicine; Biology; Cancer; Immunology; Internal medicine; Tumor cells; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451032,0.0001741744,0.0002211392,0.0001283478,0.00009146495,0.000285872,0.0001137435,0.0001468193,0.001583945],"category_scores_gemma":[0.0001037167,0.00006892707,0.0001466553,0.0001108284,0.0001317934,0.0001771577,0.0001452727,0.0003734909,0.0002996569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632385,"about_ca_system_score_gemma":0.0001853088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002900372,"about_ca_topic_score_gemma":0.0004717451,"domain_scores_codex":[0.9998962,0.00002380331,0.00001003279,0.00001690497,0.00001785722,0.00003520615],"domain_scores_gemma":[0.9999344,0.000007968549,0.00002520805,0.000006441224,0.000008097586,0.00001786378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007221665,0.0001208851,0.002591685,0.0001998829,0.000009375317,0.00005191503,0.0000301284,0.0001654116,0.9822979,0.0001285173,0.0002698444,0.01341238],"study_design_scores_gemma":[0.0001571771,0.00346357,0.03381995,0.00003135724,0.00006778417,0.0008141365,0.0001186882,0.002277485,0.9512941,0.000124841,0.007821855,0.000009102228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936953,0.003483778,0.001224446,0.0001639155,0.00002854537,0.00003634666,0.0002583269,0.00009797841,0.001011361],"genre_scores_gemma":[0.9957839,0.001007411,0.001601304,0.00008014956,0.00002343763,0.0000355496,0.0002643446,0.00001491316,0.001189068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583945,"threshold_uncertainty_score":0.005298793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008352878838006181,"score_gpt":0.2465094034176581,"score_spread":0.2381565245796519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}